Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.52 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1886694 | 0.93 | ALDH1A1 (0.46) | ALDH1A1BCHEACHEMAPTCYP1A2 | |
| Azd-3043 SCHEMBL1882795 | 0.91 | ALDH1A1 (0.46) | ALDH1A1BCHEACHEMAPTCYP1A2 | |
| SCHEMBL1882466 | 0.90 | ALDH1A1 (0.44) | ALDH1A1MAPTCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL29463785 | 0.88 | ALDH1A1 (0.56) | ALDH1A1MAPTCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL5489263 | 0.88 | ALDH1A1 (0.56) | ALDH1A1MAPTCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL12065395 | 0.87 | ALDH1A1 (0.51) | ALDH1A1BCHEACHEMAPTCYP1A2 | |
| SCHEMBL1884070 | 0.86 | BCHE (0.47) | ALDH1A1BCHEACHEMAPTCYP1A2 | |
| SCHEMBL1888610 | 0.86 | ALDH1A1 (0.46) | ALDH1A1BCHEACHEMAPTCYP1A2 | |
| SCHEMBL1883569 | 0.86 | ALDH1A1 (0.41) | ALDH1A1BCHEACHEMAPTCYP1A2 | |
| SCHEMBL1886481 | 0.86 | ALDH1A1 (0.44) | ALDH1A1BCHEACHEMAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7514425-B2 | Short-acting sedative hypnotic agents for anesthesia and sedation | THERAVANCE, INC. (US) | 2009-04-07 | — | — | US | claimed |
| US-20060116424-A1 | Short-acting sedative hypnotic agents for anesthesia and sedation | THERAVANCE BIOPHARMA R&D IP, LLC | 2006-06-01 | — | — | US | claimed |
| EP-1509492-B1 | SHORT-ACTING SEDATIVE HYPNOTIC AGENTS FOR ANESTHESIA AND SEDATION | THERAVANCE INC (US) | 2011-08-31 | — | — | EP | disclosed |
| EP-1509492-B1 | SHORT-ACTING SEDATIVE HYPNOTIC AGENTS FOR ANESTHESIA AND SEDATION | THERAVANCE INC (US) | 2011-08-31 | — | — | EP | disclosed |
| US-7939689-B2 | Short-acting sedative hypnotic agents for anesthesia and sedation | THERAVANCE, INC. (US) | 2011-05-10 | — | — | US | disclosed |
| US-7939689-B2 | Short-acting sedative hypnotic agents for anesthesia and sedation | THERAVANCE, INC. (US) | 2011-05-10 | — | — | US | disclosed |
| US-7939689-B2 | Short-acting sedative hypnotic agents for anesthesia and sedation | THERAVANCE, INC. (US) | 2011-05-10 | — | — | US | disclosed |
| US-20090253787-A1 | SHORT-ACTING SEDATIVE HYPNOTIC AGENTS FOR ANESTHESIA AND SEDATION | THERAVANCE, INC. (US) | 2009-10-08 | — | — | US | disclosed |
| US-20090253787-A1 | SHORT-ACTING SEDATIVE HYPNOTIC AGENTS FOR ANESTHESIA AND SEDATION | THERAVANCE, INC. (US) | 2009-10-08 | — | — | US | disclosed |
| US-20090253787-A1 | SHORT-ACTING SEDATIVE HYPNOTIC AGENTS FOR ANESTHESIA AND SEDATION | THERAVANCE, INC. (US) | 2009-10-08 | — | — | US | disclosed |
| US-7514425-B2 | Short-acting sedative hypnotic agents for anesthesia and sedation | THERAVANCE, INC. (US) | 2009-04-07 | — | — | US | disclosed |
| US-7514425-B2 | Short-acting sedative hypnotic agents for anesthesia and sedation | THERAVANCE, INC. (US) | 2009-04-07 | — | — | US | disclosed |
| US-20060116424-A1 | Short-acting sedative hypnotic agents for anesthesia and sedation | THERAVANCE BIOPHARMA R&D IP, LLC | 2006-06-01 | — | — | US | disclosed |
| US-7015346-B2 | Short-acting sedative hypnotic agents for anesthesia and sedation | THERAVANCE, INC. (US) | 2006-03-21 | — | — | US | disclosed |
| US-20050113364-A1 | Short-acting sedative hypnotic agents for anesthesia and sedation | THERAVANCE BIOPHARMA R&D IP, LLC | 2005-05-26 | — | — | US | disclosed |
| US-6887866-B2 | Short-acting sedative hypnotic agents for anesthesia and sedation | THERAVANCE, INC. (US) | 2005-05-03 | — | — | US | disclosed |
| EP-1509492-A2 | SHORT-ACTING SEDATIVE HYPNOTIC AGENTS FOR ANESTHESIA AND SEDATION | Theravance, Inc. (US) | 2005-03-02 | — | — | EP | disclosed |
| WO-2004037750-A2 | SHORT-ACTING SEDATIVE HYPNOTIC AGENTS FOR ANESTHESIA AND SEDATION | THERAVANCE, INC. (US) | 2004-05-06 | — | — | WO | disclosed |
| WO-2004037750-A2 | SHORT-ACTING SEDATIVE HYPNOTIC AGENTS FOR ANESTHESIA AND SEDATION | THERAVANCE, INC. (US) | 2004-05-06 | — | — | WO | disclosed |
| US-20030153554-A1 | Short-acting sedative hypnotic agents for anesthesia and sedation | THERAVANCE BIOPHARMA R&D IP, LLC | 2003-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090253787-A1 | SHORT-ACTING SEDATIVE HYPNOTIC AGENTS FOR ANESTHESIA AND SEDATION | GABRA5, GABRA6, GABRA2 | ALDH1A1 787/4885BCHE 1756/4885ACHE 706/4885 |
| US-20050113364-A1 | Short-acting sedative hypnotic agents for anesthesia and sedation | GABRA5, GABRA6, GABRA2 | ALDH1A1 787/4885BCHE 1756/4885ACHE 706/4885 |
| US-20030153554-A1 | Short-acting sedative hypnotic agents for anesthesia and sedation | GABRA5, GABRA6, GABRA2 | ALDH1A1 787/4885BCHE 1756/4885ACHE 706/4885 |
| US-20060116424-A1 | Short-acting sedative hypnotic agents for anesthesia and sedation | GABRA5, GABRA6, GABRA2 | ALDH1A1 787/4885BCHE 1756/4885ACHE 706/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.