Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NMT1 | P30419 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16503036 | 0.80 | LMNA (0.61) | TSHRLMNASMN1; SMN2HTTNMT1 | |
| SCHEMBL18903979 | 0.80 | SMN1; SMN2 (0.37) | TSHRLMNASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL18903975 | 0.76 | HTT (0.36) | LMNASMN1; SMN2HTTNMT1CYP1A2 | |
| SCHEMBL18904148 | 0.71 | NMT1 (0.40) | TSHRLMNASMN1; SMN2HTTKMT2A | |
| SCHEMBL18903922 | 0.69 | TP53 (0.44) | TSHRLMNASMN1; SMN2HTTKMT2A | |
| SCHEMBL18903943 | 0.68 | HRH3 (0.43) | LMNASMN1; SMN2HTTNMT1ALDH1A1 | |
| SCHEMBL16502976 | 0.67 | LMNA (0.63) | LMNASMN1; SMN2HTTNMT1L3MBTL1 | |
| SCHEMBL18903949 | 0.67 | HTT (0.38) | LMNASMN1; SMN2HTTNMT1CYP1A2 | |
| SCHEMBL18904149 | 0.67 | CYP11B2 (0.38) | TSHRLMNASMN1; SMN2HTTNMT1 | |
| SCHEMBL18904018 | 0.66 | NMT1 (0.65) | NMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2980076-B1 | Pyrazolyl derivatives | UNIV DUNDEE (GB) | 2017-05-31 | — | — | EP | disclosed |