Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18904190 | 0.80 | TSHR (0.37) | SMN1; SMN2LMNAHTTALDH1A1TSHR | |
| SCHEMBL18903978 | 0.78 | LMNA (0.64) | SMN1; SMN2LMNAHTT | |
| SCHEMBL18903975 | 0.73 | HTT (0.36) | SMN1; SMN2LMNAHTT | |
| SCHEMBL18903943 | 0.72 | HRH3 (0.43) | SMN1; SMN2LMNAHTTALDH1A1KDM4E | |
| SCHEMBL18903949 | 0.71 | HTT (0.38) | SMN1; SMN2LMNAHTTNPC1RAB9A | |
| SCHEMBL18904027 | 0.71 | MAPT (0.50) | SMN1; SMN2ALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL18904149 | 0.70 | CYP11B2 (0.38) | SMN1; SMN2LMNAHTTALDH1A1TSHR | |
| SCHEMBL18904018 | 0.70 | NMT1 (0.65) | — | |
| SCHEMBL18904208 | 0.70 | NMT1 (0.39) | SMN1; SMN2LMNAHTT | |
| SCHEMBL18904151 | 0.69 | NPC1 (0.42) | SMN1; SMN2LMNAHTTALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2980076-B1 | Pyrazolyl derivatives | UNIV DUNDEE (GB) | 2017-05-31 | — | — | EP | disclosed |