SCHEMBL18909221

SCHEMBL18909221

CCC(=O)N1CCC(CN2CCNCC2)CC1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GNAI3 P08754 4/20 0.47
GNAO1 P09471 4/20 0.47
GNAI1 P63096 4/20 0.47
CACNA2D1 P54289 2/20 0.46
CACNA1B Q00975 2/20 0.46
CACNB1 Q02641 2/20 0.46
EPHX2 P34913 4/20 0.43
ITGB3 P05106 2/20 0.42
ITGA2B P08514 2/20 0.42
CHRNB2 P17787 4/20 0.42
CHRNA3 P32297 4/20 0.42
CHRNA4 P43681 4/20 0.42
CHRNB4 P30926 2/20 0.42
CHRNA7 P36544 2/20 0.42
CHRNB3 Q05901 2/20 0.42
CHRNA6 Q15825 2/20 0.42
EPHX1 P07099 1/20 0.41
ALDH1A1 P00352 1/20 0.41
CACNA1C Q13936 1/20 0.40
MAPT P10636 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12507042 0.86 MAPT (0.49) EPHX2MAPT
SCHEMBL18389995 0.85 CXCR3 (0.43) GNAI3GNAO1GNAI1CACNA2D1CACNA1B
SCHEMBL22030503 0.84 GNAI3 (0.43) GNAI3GNAO1GNAI1CACNA2D1CACNA1B
SCHEMBL25571574 0.84 CACNA2D1 (0.42) GNAI3GNAO1GNAI1CACNA2D1CACNA1B
SCHEMBL29317068 0.83 ACHE (0.53) CACNA2D1CACNA1BCACNB1EPHX2EPHX1
SCHEMBL1738475 0.83 CACNA2D1 (0.45) GNAI3GNAO1GNAI1CACNA2D1CACNA1B
SCHEMBL20471042 0.82 HRH3 (0.48) CACNA2D1CACNA1BCACNB1EPHX2CHRNB2
SCHEMBL18909449 0.82 CACNA2D1 (0.45) CACNA2D1CACNA1BCACNB1EPHX2EPHX1
SCHEMBL18909230 0.82 THRB (0.53) EPHX2EPHX1
SCHEMBL25133378 0.81 CXCR3 (0.46) GNAI3GNAO1GNAI1CACNA2D1CACNA1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023093845-A1 CHIMERIC COMPOUND FOR TARGETED DEGRADATION OF ANDROGEN RECEPTOR PROTEIN, PREPARATION METHOD THEREFOR, AND MEDICAL USE THEREOF 江苏恒瑞医药股份有限公司 2023-06-01 WO disclosed
EP-3596072-B1 PYRAZOLOCHLOROPHENYL COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF HOFFMANN LA ROCHE (CH) 2022-06-22 EP disclosed
EP-3380474-B1 JANUS KINASES INHIBITORS, COMPOSITIONS THEREOF AND USE THEREOF HOFFMANN LA ROCHE (CH) 2019-08-21 EP disclosed
WO-2017140825-A1 THERAPEUTIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF F. HOFFMANN-LA ROCHE AG (CH) 2017-08-24 WO disclosed
WO-2017089390-A1 JANUS KINASES INHIBITORS, COMPOSITIONS THEREOF AND USE THEREOF F. HOFFMANN-LA ROCHE AG (CH) 2017-06-01 WO disclosed