Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | PREP | P48147 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14079949 | 0.86 | HTR1A (0.55) | KMT2ATDP1HTR1AALDH1A1SMN1; SMN2 | |
| SCHEMBL792228 | 0.83 | KMT2A (0.48) | L3MBTL1KMT2AMEN1TDP1ATM | |
| SCHEMBL14079954 | 0.82 | POLB (0.49) | L3MBTL1ALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL20842266 | 0.82 | HTR1A (0.39) | KMT2AMEN1TDP1HTR1AALDH1A1 | |
| SCHEMBL792123 | 0.82 | HSD11B1 (0.46) | KMT2AMEN1HTR1AALDH1A1KDM4E | |
| SCHEMBL18330458 | 0.81 | ALDH1A1 (0.55) | KMT2AMEN1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL11948185 | 0.80 | ATM (0.44) | L3MBTL1KMT2AMEN1TDP1ATM | |
| SCHEMBL19275358 | 0.80 | L3MBTL1 (0.48) | L3MBTL1KMT2AMEN1TDP1ATM | |
| SCHEMBL26551000 | 0.80 | L3MBTL1 (0.48) | L3MBTL1KMT2AMEN1TDP1ATM | |
| SCHEMBL20326370 | 0.78 | GNAI3 (0.39) | KMT2AMEN1PREPALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017140825-A1 | THERAPEUTIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2017-08-24 | — | — | WO | disclosed |
| WO-2017089390-A1 | JANUS KINASES INHIBITORS, COMPOSITIONS THEREOF AND USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2017-06-01 | — | — | WO | disclosed |