Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MC4R | P32245 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | MC3R | P41968 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PAK4 | O96013 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11769997 | 0.84 | ALDH1A1 (0.65) | ALDH1A1HPGDALOX15HSD17B10POLB | |
| SCHEMBL851358 | 0.79 | ALDH1A1 (0.69) | ALDH1A1HPGDALOX15HSD17B10RAB9A | |
| SCHEMBL29540343 | 0.79 | ALDH1A1 (0.69) | ALDH1A1HPGDALOX15HSD17B10RAB9A | |
| Hydrochloric Acid SCHEMBL29488564 | 0.78 | ALDH1A1 (0.67) | ALDH1A1HPGDALOX15HSD17B10RAB9A | |
| SCHEMBL3282791 | 0.76 | ADORA3 (0.46) | ADORA3TSHRMC4RADRA1AMC3R | |
| SCHEMBL17540964 | 0.76 | ADORA3 (0.46) | ADORA3TSHRMC4RADRA1AMC3R | |
| SCHEMBL31603641 | 0.72 | TGFBR1 (0.43) | ADORA3TSHRMC4RADRA1AMC3R | |
| SCHEMBL21591634 | 0.71 | KDM4E (0.39) | ADORA3ALDH1A1POLBMAP4K4CDK8 | |
| Cinnoline SCHEMBL5471704 | 0.70 | ALDH1A1 (0.51) | ALDH1A1HPGDALOX15HSD17B10POLB | |
| SCHEMBL5314248 | 0.70 | HPGDS (0.51) | ADORA3TSHRMC4RADRA1AMC3R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9670206-B2 | Pyrido[4,3-B]pyrazine-2-carboxamides as neurogenic agents for the treatment of neurodegenerative disorders | HOFFMANN-LA ROCHE INC. (US) | 2017-06-06 | — | — | US | disclosed |
| CN-105764901-A | Pyrido[4,3-B]pyrazine-2-carboxamides as neurogenic agents for the treatment of neurodegenerative disorders | 豪夫迈·罗氏有限公司 | 2016-07-13 | — | — | CN | disclosed |