SCHEMBL18921817

SCHEMBL18921817

COc1ccc2[nH]c(NCc3cc(OC)c4c(OC)ccc(OC)c4c3OC)nc2c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.48
SMN1; SMN2 Q16637 2/20 0.47
TP53 P04637 1/20 0.47
RAB9A P51151 1/20 0.47
ALDH1A1 P00352 3/20 0.44
DHFR P00374 3/20 0.40
MAPT P10636 4/20 0.39
KDM4E B2RXH2 2/20 0.39
APAF1 O14727 2/20 0.39
RECQL P46063 1/20 0.39
PDE9A O76083 3/20 0.39
NPC1 O15118 1/20 0.38
ALOX15 P16050 1/20 0.38
MAPK1 P28482 1/20 0.38
CASP1 P29466 1/20 0.38
CASP7 P55210 1/20 0.38
HSD17B10 Q99714 1/20 0.38
IDH1 O75874 1/20 0.38
PKM P14618 1/20 0.37
GFER P55789 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18921841 0.89 GAA (0.48) GAASMN1; SMN2TP53RAB9AALDH1A1
SCHEMBL18921833 0.88 GAA (0.47) GAASMN1; SMN2TP53RAB9AMAPT
SCHEMBL18921838 0.88 GAA (0.47) GAASMN1; SMN2TP53RAB9AALDH1A1
SCHEMBL18921832 0.87 GAA (0.65) GAASMN1; SMN2TP53RAB9AALDH1A1
SCHEMBL18921815 0.72 GAA (0.66) GAASMN1; SMN2TP53RAB9AALDH1A1
SCHEMBL18921823 0.72 NPC1 (0.43) GAASMN1; SMN2RAB9AALDH1A1DHFR
SCHEMBL6759841 0.70 RAB9A (0.62) GAASMN1; SMN2TP53RAB9AALDH1A1
SCHEMBL18921814 0.69 NPC1 (0.45) GAASMN1; SMN2RAB9AALDH1A1MAPT
SCHEMBL10642154 0.68 PKM (0.72) GAASMN1; SMN2TP53RAB9AALDH1A1
SCHEMBL24847112 0.68 FPR2 (0.56) SMN1; SMN2TP53RAB9AALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017095051-A2 COMPOSITION CONTAINING NAPHTHOQUINONE DERIVATIVE FOR CONTROLLING HARMFUL ALGAE AND METHOD FOR CONTROLLING HARMFUL ALGAE USING SAME 한양대학교 산학협력단 2017-06-08 WO disclosed