Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 1/20 | 0.56 |
| ▸ | ENPP1 | P22413 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.47 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29802130 | 1.00 | FPR2 (0.56) | FPR2ENPP1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL24846568 | 0.79 | ALDH1A1 (0.45) | FPR2ENPP1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL24846611 | 0.75 | MAPT (0.63) | ALDH1A1SMN1; SMN2LMNAKDM4EHPGD | |
| SCHEMBL31265132 | 0.73 | TUBB4A (0.61) | ALDH1A1SMN1; SMN2LMNAHPGDL3MBTL1 | |
| SCHEMBL31534664 | 0.72 | MEN1 (0.46) | FPR2ALDH1A1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL24846628 | 0.71 | ALDH1A1 (0.55) | FPR2ALDH1A1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL31265130 | 0.71 | LMNA (0.53) | ALDH1A1SMN1; SMN2LMNAKDM4EHPGD | |
| SCHEMBL10198313 | 0.70 | SMN1; SMN2 (0.64) | ALDH1A1SMN1; SMN2LMNAKDM4EHPGD | |
| SCHEMBL19427517 | 0.70 | HSD17B10 (0.60) | FPR2ALDH1A1SMN1; SMN2POLBCYP1A2 | |
| SCHEMBL2953775 | 0.70 | KMT2A (0.55) | ALDH1A1SMN1; SMN2LMNAKDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230002387-A1 | 2-AMINO-S6-SUBSTITUTED THIOPURINE COMPOUNDS AS INHIBITORS OF THE ENPP1 PROTEIN | ATEN PORUS LIFESCIENCES PVT. LTD. (IN) | 2023-01-05 | — | — | US | disclosed |
| CN-114728971-A | 2-amino-S6-substituted thiopurine compounds as inhibitors of ENPP1 protein | 阿托恩波罗斯生命科学私人有限公司 | 2022-07-08 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230002387-A1 | 2-AMINO-S6-SUBSTITUTED THIOPURINE COMPOUNDS AS INHIBITORS OF THE ENPP1 PROTEIN | ENPP1, ENPP3, PNP | FPR2 2212/4885ENPP1 1/4885ALDH1A1 3259/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.