Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | F10 | P00742 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | LOX | P28300 | 1/20 | 0.37 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19569894 | 0.92 | F10 (0.41) | KMT2AHTTF10ALDH1A1GAA | |
| SCHEMBL21909060 | 0.89 | KMT2A (0.48) | KMT2AHTTF10ALDH1A1SMN1; SMN2 | |
| SCHEMBL18923792 | 0.85 | F10 (0.43) | KMT2AHTTF10ALDH1A1GAA | |
| SCHEMBL25571882 | 0.85 | F10 (0.43) | KMT2AHTTF10ALDH1A1GAA | |
| SCHEMBL23106249 | 0.84 | ALDH1A1 (0.42) | KMT2AHTTF10ALDH1A1GAA | |
| SCHEMBL23809542 | 0.83 | F10 (0.40) | KMT2AHTTF10ALDH1A1GAA | |
| SCHEMBL24346423 | 0.83 | SMN1; SMN2 (0.49) | KMT2AHTTF10ALDH1A1GAA | |
| SCHEMBL21575546 | 0.82 | ALDH1A1 (0.37) | KMT2AHTTF10ALDH1A1GAA | |
| SCHEMBL23809317 | 0.81 | NR1H4 (0.40) | KMT2AHTTF10ALDH1A1GAA | |
| SCHEMBL23106243 | 0.81 | SMN1; SMN2 (0.38) | KMT2AHTTF10ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220112552-A1 | DESIGN AND SYNTHESIS OF CLEAVABLE FLUORESCENT NUCLEOTIDES AS REVERSIBLE TERMINATORS FOR DNA SEQUENCING BY SYNTHESIS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2022-04-14 | — | — | US | disclosed |
| US-11242561-B2 | DNA sequencing with non-fluorescent nucleotide reversible terminators and cleavable label modified nucleotide terminators | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2022-02-08 | — | — | US | disclosed |
| US-11208691-B2 | Synthesis of cleavable fluorescent nucleotides as reversible terminators for DNA sequencing by synthesis | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2021-12-28 | — | — | US | disclosed |
| US-10260094-B2 | DNA sequencing with non-fluorescent nucleotide reversible terminators and cleavable label modified nucleotide terminators | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2019-04-16 | — | — | US | disclosed |
| US-20190085388-A1 | DESIGN AND SYNTHESIS OF CLEAVABLE FLUORESCENT NUCLEOTIDES AS REVERSIBLE TERMINATORS FOR DNA SEQUENCING BY SYNTHESIS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2019-03-21 | — | — | US | disclosed |
| US-20170321267-A1 | DESIGN AND SYNTHESIS OF CLEAVABLE FLUORESCENT NUCLEOTIDES AS REVERSIBLE TERMINATORS FOR DNA SEQUENCING BY SYNTHESIS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-11-09 | — | — | US | disclosed |
| US-9670539-B2 | Synthesis of cleavable fluorescent nucleotides as reversible terminators for DNA sequencing by synthesis | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220112552-A1 | DESIGN AND SYNTHESIS OF CLEAVABLE FLUORESCENT NUCLEOTIDES AS REVERSIBLE TERMINATORS FOR DNA SEQUENCING BY SYNTHESIS | RNGTT, TYMS, DUT | KMT2A 1554/4885HTT 1003/4885F10 4141/4885 |
| US-11208691-B2 | Synthesis of cleavable fluorescent nucleotides as reversible terminators for DNA sequencing by synthesis | TYMS, DUT, DNTT | KMT2A 1500/4885HTT 1111/4885F10 3933/4885 |
| US-11242561-B2 | DNA sequencing with non-fluorescent nucleotide reversible terminators and cleavable label modified nucleotide terminators | RNGTT, DNTT, TYMP | KMT2A 1749/4885HTT 746/4885F10 4114/4885 |
| US-20170321267-A1 | DESIGN AND SYNTHESIS OF CLEAVABLE FLUORESCENT NUCLEOTIDES AS REVERSIBLE TERMINATORS FOR DNA SEQUENCING BY SYNTHESIS | RNGTT, TYMS, DUT | KMT2A 1554/4885HTT 1003/4885F10 4141/4885 |
| US-20190085388-A1 | DESIGN AND SYNTHESIS OF CLEAVABLE FLUORESCENT NUCLEOTIDES AS REVERSIBLE TERMINATORS FOR DNA SEQUENCING BY SYNTHESIS | RNGTT, TYMS, DUT | KMT2A 1554/4885HTT 1003/4885F10 4141/4885 |
| US-10260094-B2 | DNA sequencing with non-fluorescent nucleotide reversible terminators and cleavable label modified nucleotide terminators | RNGTT, NT5C3B, DNTT | KMT2A 2031/4885HTT 814/4885F10 3637/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.