Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | FBP1 | P09467 | 7/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 3/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16552188 | 0.77 | L3MBTL1 (0.40) | ALDH1A1HPGDKDM4EHSD17B10GPR35 | |
| SCHEMBL17362509 | 0.67 | HSD17B10 (0.49) | ALDH1A1KDM4EHSD17B10GPR35L3MBTL1 | |
| SCHEMBL15999650 | 0.66 | L3MBTL1 (0.41) | ALDH1A1HPGDKDM4EHSD17B10GPR35 | |
| SCHEMBL28813054 | 0.65 | ALDH1A1 (0.39) | ALDH1A1HPGDFBP1L3MBTL1LMNA | |
| SCHEMBL30499570 | 0.65 | MEN1 (0.54) | ALDH1A1KDM4EHSD17B10GPR35LMNA | |
| SCHEMBL30499537 | 0.65 | DPP4 (0.42) | ALDH1A1HPGDKDM4EHSD17B10GPR35 | |
| SCHEMBL9948150 | 0.65 | MEN1 (0.54) | ALDH1A1KDM4EHSD17B10GPR35LMNA | |
| SCHEMBL29052481 | 0.65 | MEN1 (0.45) | ALDH1A1KDM4EHSD17B10GPR35L3MBTL1 | |
| SCHEMBL25195217 | 0.64 | PLAU (0.37) | ALDH1A1KDM4EL3MBTL1LMNASMN1; SMN2 | |
| SCHEMBL30276192 | 0.64 | THRB (0.40) | ALDH1A1HPGDKDM4EHSD17B10FBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3176172-A1 | SPIROIMIDAZOLE COMPOUNDS AND THEIR USE AS BACE INHIBITORS | Astrazeneca AB (SE) | 2017-06-07 | — | — | EP | disclosed |