Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | CCNC | P24863 | 2/20 | 0.46 |
| ▸ | CDK8 | P49336 | 2/20 | 0.46 |
| ▸ | KLKB1 | P03952 | 5/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17790720 | 0.83 | ROCK2 (0.57) | KDM4ECCNCCDK8KLKB1L3MBTL1 | |
| SCHEMBL13555495 | 0.73 | L3MBTL1 (0.58) | KDM4EL3MBTL1POLBTDP1SLC7A5 | |
| SCHEMBL2713277 | 0.71 | CREBBP (0.55) | KDM4EKLKB1L3MBTL1POLBTDP1 | |
| SCHEMBL28655081 | 0.71 | FGFR1 (0.53) | CCNCCDK8L3MBTL1NAMPTRAB9A | |
| SCHEMBL22557105 | 0.71 | ALDH1A1 (0.55) | KDM4EKLKB1HPGDALDH1A1 | |
| SCHEMBL2712569 | 0.70 | L3MBTL1 (0.60) | KLKB1L3MBTL1POLBTDP1ALK | |
| SCHEMBL3713180 | 0.69 | L3MBTL1 (0.62) | KLKB1L3MBTL1POLBTDP1ALK | |
| SCHEMBL29778420 | 0.68 | WNT1 (0.51) | CCNCCDK8ALKROCK2 | |
| SCHEMBL29135953 | 0.68 | WNT1 (0.51) | CCNCCDK8ALKROCK2 | |
| SCHEMBL14699418 | 0.67 | KLKB1 (0.60) | KDM4EKLKB1L3MBTL1POLBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3016950-B1 | TRICYCLIC PYRIDO-CARBOXAMIDE DERIVATIVES AS ROCK INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2017-06-07 | — | — | EP | disclosed |