Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 7/20 | 0.54 |
| ▸ | BCL2 | P10415 | 4/20 | 0.54 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | BCL2A1 | Q16548 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PKLR | P30613 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | APAF1 | O14727 | 1/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1892299 | 0.78 | SLC37A4 (0.43) | BCL2L1BCL2MCL1BCL2A1MAPT | |
| SCHEMBL1893025 | 0.77 | BCL2 (0.50) | BCL2L1BCL2MCL1BCL2A1HSD17B10 | |
| SCHEMBL1889138 | 0.76 | PGAM1 (0.45) | BCL2L1BCL2MCL1BCL2A1L3MBTL1 | |
| SCHEMBL16384433 | 0.75 | ALDH1A1 (0.47) | LMNAHSD17B10MEN1HPGDKMT2A | |
| SCHEMBL19038887 | 0.74 | BCL2 (0.45) | BCL2MCL1HSD17B10MAPTMEN1 | |
| SCHEMBL16384445 | 0.74 | BCL2 (0.60) | BCL2L1BCL2MCL1LMNABCL2A1 | |
| SCHEMBL1885850 | 0.72 | ESR1 (0.40) | BCL2MCL1MAPTHTTKDM4E | |
| SCHEMBL353855 | 0.70 | BCL2L1 (1.00) | BCL2L1BCL2MCL1LMNABCL2A1 | |
| SCHEMBL19424216 | 0.69 | BCL2 (0.40) | BCL2L1BCL2MCL1BCL2A1HSD17B10 | |
| SCHEMBL1890127 | 0.69 | BCL2L1 (0.38) | BCL2L1BCL2MCL1BCL2A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8937193-B2 | Apogossypolone derivatives as anticancer agents | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2015-01-20 | — | — | US | disclosed |
| US-20110112112-A1 | APOGOSSYPOLONE DERIVATIVES AS ANTICANCER AGENTS | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2011-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110112112-A1 | APOGOSSYPOLONE DERIVATIVES AS ANTICANCER AGENTS | CYP17A1, HSD17B7, CYP27A1 | BCL2L1 195/4885BCL2 142/4885MCL1 34/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.