Y-27632

Y-27632

SCHEMBL18935698

C[C@@H](N)[C@H]1CC[C@@H](C(=O)Nc2ccncc2)CC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ROCK2 O75116 8/20 1.00
ROCK1 Q13464 8/20 1.00
PKN2 Q16513 4/20 1.00
RPS6KA5 O75582 3/20 1.00
LRRK2 Q5S007 3/20 1.00
TP53 P04637 2/20 1.00
CYP3A4 P08684 2/20 1.00
PRKD3 O94806 2/20 1.00
CDK1 P06493 2/20 1.00
CDK2 P24941 2/20 1.00
LTK P29376 2/20 1.00
CDK8 P49336 2/20 1.00
PRKX P51817 2/20 1.00
PRKCQ Q04759 2/20 1.00
PRKCD Q05655 2/20 1.00
STK3 Q13188 2/20 1.00
CDC42BPA Q5VT25 2/20 1.00
BRSK1 Q8TDC3 2/20 1.00
CLK4 Q9HAZ1 2/20 1.00
TSHR P16473 2/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Y-27632 SCHEMBL28416532 1.00 ROCK2 (1.00) ROCK2ROCK1PKN2RPS6KA5LRRK2
Y-27632 SCHEMBL598993 1.00 ROCK2 (1.00) ROCK2ROCK1PKN2RPS6KA5LRRK2
Y-27632 SCHEMBL190356 1.00 ROCK2 (1.00) ROCK2ROCK1PKN2RPS6KA5LRRK2
Y-27632 SCHEMBL1980406 1.00 ROCK2 (1.00) ROCK2ROCK1PKN2RPS6KA5LRRK2
Y-27632 SCHEMBL20333114 1.00 ROCK2 (1.00) ROCK2ROCK1PKN2RPS6KA5LRRK2
Y-27632 SCHEMBL342816 1.00 ROCK2 (1.00) ROCK2ROCK1PKN2RPS6KA5LRRK2
Y-27632 SCHEMBL30286315 1.00 ROCK2 (1.00) ROCK2ROCK1PKN2RPS6KA5LRRK2
Y-27632 SCHEMBL2796890 0.99 ROCK2 (0.97) ROCK2ROCK1PKN2RPS6KA5LRRK2
Y-27632 SCHEMBL1554110 0.99 ROCK2 (1.00) ROCK2ROCK1PKN2RPS6KA5LRRK2
Y-27632 SCHEMBL2834049 0.99 ROCK2 (1.00) ROCK2ROCK1PKN2RPS6KA5LRRK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10655105-B2 Method for proliferation of pancreatic progenitor cells TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2020-05-19 US claimed
EP-4397749-A1 KIDNEY ORGANOID AND METHOD FOR PRODUCING SAME Otsuka Pharmaceutical Co., Ltd. (JP) 2024-07-10 EP disclosed
US-20240124846-A1 GROWTH INHIBITOR Orizuru Therapeutics, Inc. (JP) 2024-04-18 US disclosed
EP-3450546-B1 SKELETAL MUSCLE PRECURSOR CELLS AND PRODUCTION METHOD FOR SKELETAL MUSCLE CELLS TAKEDA PHARMACEUTICALS CO (JP) 2024-03-13 EP disclosed
WO-2024014497-A1 FIBRIN GEL SHEET FOR CELL TRANSPLANTATION オリヅルセラピューティクス株式会社 2024-01-18 WO disclosed
EP-4293105-A1 MATURATION AGENT Orizuru Therapeutics, Inc. (JP) 2023-12-20 EP disclosed
WO-2023210578-A1 MATURING AGENT HAVING BOTH OF ALK5 INHIBITORY ACTIVITY AND CDK8/19 INHIBITORY ACTIVITY オリヅルセラピューティクス株式会社 2023-11-02 WO disclosed
EP-4249587-A1 MATURATION AGENT Orizuru Therapeutics, Inc. (JP) 2023-09-27 EP disclosed
EP-3954436-A1 METHOD FOR PRODUCING BIOTISSUE-LIKE STRUCTURE Orizuru Therapeutics, Inc. (JP) 2022-02-16 EP disclosed
US-20210371818-A1 METHOD FOR INDUCING DIFFERENTIATION OF CORNEAL EPITHELIAL CELLS FROM PLURIPOTENT STEM CELLS OSAKA UNIVERSITY (JP) 2021-12-02 US disclosed
EP-3812456-A1 GROWTH INHIBITOR Kyoto University (JP) 2021-04-28 EP disclosed
US-20210060210-A1 HYDROGEL CAPSULE KYOTO UNIVERSITY (JP) 2021-03-04 US disclosed
EP-3770253-A1 HYDROGEL CAPSULE Kyoto University (JP) 2021-01-27 EP disclosed
US-10655105-B2 Method for proliferation of pancreatic progenitor cells TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2020-05-19 US disclosed
EP-3178924-B1 METHOD FOR PROLIFERATION OF PANCREATIC PROGENITOR CELLS TAKEDA PHARMACEUTICALS CO (JP) 2019-12-25 EP disclosed
US-20190338251-A1 Skeletal Muscle Precursor Cells and Production Method for Skeletal Muscle Cells TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2019-11-07 US disclosed
US-20180010093-A1 METHOD FOR INDUCING DIFFERENTIATION OF CORNEAL EPITHELIAL CELLS FROM PLURIPOTENT STEM CELLS OSAKA UNIVERSITY (JP) 2018-01-11 US disclosed
EP-3246394-A1 METHOD FOR INDUCING DIFFERENTIATION OF CORNEAL EPITHELIAL CELLS FROM PLURIPOTENT STEM CELLS Osaka University (JP) 2017-11-22 EP disclosed
US-20170233700-A1 Method for Proliferation of Pancreatic Progenitor Cells TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2017-08-17 US disclosed
EP-3178924-A1 METHOD FOR PROLIFERATION OF PANCREATIC PROGENITOR CELLS Takeda Pharmaceutical Company Limited (JP) 2017-06-14 EP disclosed