Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 4/20 | 0.43 |
| ▸ | MAOA | P21397 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA3 | P07451 | 1/20 | 0.41 |
| ▸ | CA6 | P23280 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15212297 | 0.76 | MAOB (0.50) | ALDH1A1CYP2A6CA2CA9CA1 | |
| SCHEMBL103904 | 0.73 | MAOB (0.61) | ALDH1A1CYP2A6CA2CA9CA1 | |
| SCHEMBL30757515 | 0.73 | MAOB (0.61) | ALDH1A1CYP2A6CA2CA9CA1 | |
| 1,4-Dimethoxybenzene SCHEMBL28617696 | 0.73 | MAOB (0.61) | ALDH1A1CYP2A6CA2CA9CA1 | |
| SCHEMBL2707459 | 0.72 | PARP15 (0.49) | ALDH1A1CYP2A6CA2CA9CA1 | |
| SCHEMBL23566017 | 0.72 | CA2 (0.52) | ALDH1A1CYP2A6CA2CA9CA1 | |
| SCHEMBL8852392 | 0.72 | PARP15 (0.63) | ALDH1A1CYP2A6CA2CA9CA1 | |
| SCHEMBL7041250 | 0.72 | PARP15 (0.63) | ALDH1A1CYP2A6CA2CA9CA1 | |
| SCHEMBL30250275 | 0.71 | MAOA (0.59) | ALDH1A1CYP2A6CA2CA9CA1 | |
| SCHEMBL2503454 | 0.71 | CA2 (0.69) | ALDH1A1CYP2A6CA2CA9CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10301283-B2 | 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1h-tetrazol-1-yl)propan-2-ols and processes for their preparation | DOW AGROSCIENCES, LLC (US) | 2019-05-28 | — | — | US | disclosed |
| US-20180155324-A1 | 2-(2,4-DIFLUOROPHENYL)-1,1-DIFLUORO-1-(5-SUBSTITUTED-PYRIDIN-2-YL)-3-(1H-TETRAZOL-1-YL)PROPAN-2-OLS AND PROCESSES FOR THEIR PREPARATION | CORTEVA AGRISCIENCE LLC | 2018-06-07 | — | — | US | disclosed |
| US-9988365-B2 | 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ols and processes for their preparation | VPS-3, INC. (US) | 2018-06-05 | — | — | US | disclosed |
| US-20170158667-A1 | 2-(2,4-DIFLUOROPHENYL)-1,1-DIFLUORO-1-(5-SUBSTITUTED-PYRIDIN-2-YL)-3-(1H-TETRAZOL-1-YL)PROPAN-2-OLS AND PROCESSES FOR THEIR PREPARATION | VIAMET PHARMACEUTICALS, INC. | 2017-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170158667-A1 | 2-(2,4-DIFLUOROPHENYL)-1,1-DIFLUORO-1-(5-SUBSTITUTED-PYRIDIN-2-YL)-3-(1H-TETRAZOL-1-YL)PROPAN-2-OLS AND PROCESSES FOR THEIR PREPARATION | PDXK, PFKFB1, PDGFRA | ALDH1A1 476/4885CYP2A6 2047/4885CA2 4774/4885 |
| US-20180155324-A1 | 2-(2,4-DIFLUOROPHENYL)-1,1-DIFLUORO-1-(5-SUBSTITUTED-PYRIDIN-2-YL)-3-(1H-TETRAZOL-1-YL)PROPAN-2-OLS AND PROCESSES FOR THEIR PREPARATION | PDXK, PFKFB1, PDGFRA | ALDH1A1 476/4885CYP2A6 2047/4885CA2 4774/4885 |
| US-10301283-B2 | 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1h-tetrazol-1-yl)propan-2-ols and processes for their preparation | PDXK, PFKFB1, PDGFRA | ALDH1A1 476/4885CYP2A6 2047/4885CA2 4774/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.