⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21087447 | 0.80 | ALDH1A1 (0.30) | — | |
| SCHEMBL18947603 | 0.70 | ATM (0.42) | — | |
| SCHEMBL12636376 | 0.67 | PDE4A (0.34) | — | |
| SCHEMBL16564470 | 0.67 | PDXK (0.41) | — | |
| SCHEMBL31164468 | 0.67 | CHRNB2 (0.31) | — | |
| SCHEMBL11800359 | 0.67 | HTT (0.33) | — | |
| SCHEMBL21672295 | 0.67 | ALDH1A1 (0.39) | — | |
| SCHEMBL20617544 | 0.67 | MEN1 (0.32) | — | |
| SCHEMBL10170378 | 0.67 | HTT (0.39) | — | |
| SCHEMBL16564446 | 0.67 | CA2 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10544161-B2 | Anti-fibrotic pyridinones | INTERMUNE, INC. (US) | 2020-01-28 | — | — | US | disclosed |
| US-20190144467-A1 | ANTI-FIBROTIC PYRIDINONES | GENENTECH, INC. | 2019-05-16 | — | — | US | disclosed |
| US-9675593-B2 | Anti-fibrotic pyridinones | INTERMUNE, INC. (US) | 2017-06-13 | — | — | US | disclosed |