Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 6/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6630838 | 0.84 | TAS2R14 (0.46) | TAS2R14HSD11B1NOTUMCTSSALDH1A1 | |
| SCHEMBL18966067 | 0.81 | TAS2R14 (0.39) | TAS2R14HSD11B1NOTUMCTSSALDH1A1 | |
| SCHEMBL11955140 | 0.76 | CA2 (0.46) | TAS2R14HSD11B1NOTUMCTSSALDH1A1 | |
| SCHEMBL28702822 | 0.75 | TAS2R14 (0.41) | TAS2R14HSD11B1NOTUMCTSSALDH1A1 | |
| SCHEMBL31156210 | 0.75 | TAS2R14 (0.41) | TAS2R14HSD11B1NOTUMCTSSALDH1A1 | |
| SCHEMBL911639 | 0.74 | TRPA1 (0.56) | TAS2R14HSD11B1NOTUMCTSSALDH1A1 | |
| SCHEMBL18753330 | 0.74 | NOTUM (0.42) | TAS2R14HSD11B1NOTUMCTSSALDH1A1 | |
| SCHEMBL3821590 | 0.73 | TRPA1 (0.48) | TAS2R14HSD11B1NOTUMCTSSALDH1A1 | |
| SCHEMBL30867018 | 0.73 | TRPA1 (0.48) | TAS2R14HSD11B1NOTUMCTSSALDH1A1 | |
| SCHEMBL20342924 | 0.72 | NOTUM (0.41) | TAS2R14HSD11B1NOTUMCTSSALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432321-B1 | THIAZOLOPYRIMIDINONE DERIVATIVES AS PI3 KINASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2017-06-14 | — | — | EP | disclosed |