SCHEMBL1898392

SCHEMBL1898392

O=C(Nc1ncnc2nc[nH]c12)c1ccco1

nearest known ligand 0.64

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 13/20 0.64
NT5C2 P49902 2/20 0.59
NT5E P21589 1/20 0.57
KDR P35968 2/20 0.55
TP53 P04637 2/20 0.55
MEN1 O00255 1/20 0.55
CYP1A2 P05177 1/20 0.55
ADORA3 P0DMS8 1/20 0.55
ALOX15 P16050 1/20 0.55
TSHR P16473 1/20 0.55
KMT2A Q03164 1/20 0.55
SMN1; SMN2 Q16637 1/20 0.55
HIF1A Q16665 1/20 0.55
CREBBP Q92793 1/20 0.55
RAB9A P51151 2/20 0.51
NPC1 O15118 1/20 0.51
MAPT P10636 1/20 0.50
ATM Q13315 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1898390 0.81 RAB9A (0.51) TP53MEN1CYP1A2TSHRKMT2A
SCHEMBL23124 0.79 BRD4 (1.00) BRD4NT5C2NT5ECREBBPRAB9A
SCHEMBL29514799 0.79 BRD4 (1.00) BRD4NT5C2NT5ECREBBPRAB9A
SCHEMBL8381776 0.77 BRD4 (0.97) BRD4NT5C2NT5ECREBBPRAB9A
SCHEMBL9801799 0.77 SMN1; SMN2 (0.61) BRD4KDRTP53MEN1CYP1A2
SCHEMBL6463477 0.75 BRD4 (0.92) BRD4NT5C2NT5ECREBBP
SCHEMBL38666421 0.75 BRD4 (0.66) BRD4NT5C2NT5ETP53MEN1
SCHEMBL22118772 0.74 BRD4 (0.68) BRD4NT5C2NT5ETP53CYP1A2
Kinetin SCHEMBL15941491 0.73 SMN1; SMN2 (0.86) BRD4KDRTP53MEN1CYP1A2
SCHEMBL5437612 0.73 BRD4 (0.62) BRD4NT5C2NT5ETP53CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1901817-A2 PERSONAL CARE COMPOSITIONS AND METHODS FOR THE BEAUTIFICATION OF MAMMALIAN SKIN AND HAIR The Procter and Gamble Company (US) 2008-03-26 EP claimed
WO-2007007255-A2 PERSONAL CARE COMPOSITIONS AND METHODS FOR THE BEAUTIFICATION OF MAMMALIAN SKIN AND HAIR THE PROCTER & GAMBLE COMPANY (US) 2007-01-18 WO claimed
US-20070009474-A1 Personal care compositions and methods for the beautification of mammalian skin and hair THE PROCTER & GAMBLE COMPANY 2007-01-11 US claimed
EP-2498772-B1 COMPOSITION AND METHODS FOR IMPROVING SKIN APPEARANCE SYTHEON LTD (US) 2025-07-30 EP disclosed
US-8496917-B2 Compositions and methods for improving skin appearance SYTHEON LTD (US) 2013-07-30 US disclosed
US-20130183257-A1 COMPOSITIONS AND METHODS FOR IMPROVING SKIN APPEARANCE SYTHEON LTD. (US) 2013-07-18 US disclosed
EP-2498772-A2 COMPOSITION AND METHODS FOR IMPROVING SKIN APPEARANCE Sytheon Ltd. (US) 2012-09-19 EP disclosed
US-20110117036-A1 Compositions and Methods for Improving Skin Appearance SYTHEON LIMITED (US) 2011-05-19 US disclosed
WO-2011059866-A2 COMPOSITION AND METHODS FOR IMPROVING SKIN APPEARANCE SYTHEON LTD. (US) 2011-05-19 WO disclosed
US-20080076720-A1 Personal care compositions having kinetin or zeatin THE PROCTER & GAMBLE COMPANY 2008-03-27 US disclosed
EP-1901817-A2 PERSONAL CARE COMPOSITIONS AND METHODS FOR THE BEAUTIFICATION OF MAMMALIAN SKIN AND HAIR The Procter and Gamble Company (US) 2008-03-26 EP disclosed
EP-1901817-A2 PERSONAL CARE COMPOSITIONS AND METHODS FOR THE BEAUTIFICATION OF MAMMALIAN SKIN AND HAIR The Procter and Gamble Company (US) 2008-03-26 EP disclosed
WO-2007007255-A3 PERSONAL CARE COMPOSITIONS AND METHODS FOR THE BEAUTIFICATION OF MAMMALIAN SKIN AND HAIR PROCTER & GAMBLE (US) 2007-03-29 WO disclosed
WO-2007007255-A2 PERSONAL CARE COMPOSITIONS AND METHODS FOR THE BEAUTIFICATION OF MAMMALIAN SKIN AND HAIR THE PROCTER & GAMBLE COMPANY (US) 2007-01-18 WO disclosed
WO-2007007255-A2 PERSONAL CARE COMPOSITIONS AND METHODS FOR THE BEAUTIFICATION OF MAMMALIAN SKIN AND HAIR THE PROCTER & GAMBLE COMPANY (US) 2007-01-18 WO disclosed
US-20070009474-A1 Personal care compositions and methods for the beautification of mammalian skin and hair THE PROCTER & GAMBLE COMPANY 2007-01-11 US disclosed
US-20070009474-A1 Personal care compositions and methods for the beautification of mammalian skin and hair THE PROCTER & GAMBLE COMPANY 2007-01-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110117036-A1 Compositions and Methods for Improving Skin Appearance CUTA, C5, C1S BRD4 4380/4885NT5C2 2549/4885NT5E 1637/4885
US-20130183257-A1 COMPOSITIONS AND METHODS FOR IMPROVING SKIN APPEARANCE CUTA, C5, C1S BRD4 4380/4885NT5C2 2549/4885NT5E 1637/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.