Sugi Predict

Sugi Predict / Compounds / SCHEMBL1899307

SCHEMBL1899307

SCHEMBL1899307

CCCN(CCC)c1cc2c(cc1CN(Cc1cccc(C)c1)C(=O)OC)CCC2

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ DUSP3 P51452 1/20 0.37
▸ PTPN5 P54829 1/20 0.37
▸ PTPN11 Q06124 1/20 0.37
▸ PTGES O14684 1/20 0.36
▸ CETP P11597 2/20 0.35
▸ NPC1 O15118 2/20 0.35
▸ RAB9A P51151 1/20 0.35
▸ ACHE P22303 1/20 0.35
▸ PPARA Q07869 2/20 0.35
▸ ALDH1A1 P00352 4/20 0.34
▸ KDM4E B2RXH2 3/20 0.34
▸ HPGD P15428 2/20 0.34
▸ MAPT P10636 2/20 0.34
▸ PPARG P37231 1/20 0.34
▸ DRD2 P14416 1/20 0.33
▸ DRD3 P35462 1/20 0.33
▸ GHSR Q92847 1/20 0.33
▸ RORC P51449 1/20 0.33
▸ MEN1 O00255 1/20 0.33
▸ POLB P06746 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1902763 0.90 DUSP3 (0.39) DUSP3PTPN5PTPN11CETPNPC1
SCHEMBL1902779 0.89 HTT (0.39) DUSP3PTPN5PTPN11PTGESPPARA
SCHEMBL1901365 0.89 LOXL2 (0.40) RAB9AALDH1A1KDM4EMAPTSMN1; SMN2
SCHEMBL1899532 0.87 CETP (0.45) PTGESCETPSMN1; SMN2
SCHEMBL5670550 0.82 NR3C1 (0.43) CETPALDH1A1KDM4EPPARG
SCHEMBL1897766 0.80 CETP (0.49) CETP
SCHEMBL1896849 0.80 CETP (0.37) DUSP3PTPN5PTPN11CETPNPC1
SCHEMBL5670345 0.80 PKM (0.40) ALDH1A1MAPTMEN1KMT2A
SCHEMBL1900110 0.79 CETP (0.49) CETPSMN1; SMN2
SCHEMBL5670858 0.78 LIMK1 (0.40) PTGESALDH1A1GHSRRORCPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070054839-A1 Method of inhibiting remnant lipoprotein production JAPAN TOBACCO INC. (JP) 2007-03-08 — — US claimed
US-20060270705-A1 Method for inhibiting lipid absorption and lipid absorption inhibitor JAPAN TOBACCO INC. (JP) 2006-11-30 — — US claimed
US-20110189210-A1 METHOD OF INHIBITING REMNANT LIPOPROTEIN PRODUCTION JAPAN TOBACCO INC. (JP) 2011-08-04 — — US disclosed
EP-2319509-A1 Method of Inhibiting remnant lipoprotein production Japan Tobacco, Inc. (JP) 2011-05-11 — — EP disclosed
EP-2316447-A1 Method of inhibiting remnant lipoprotein production Japan Tobacco, Inc. (JP) 2011-05-04 — — EP disclosed
US-20070054839-A1 Method of inhibiting remnant lipoprotein production JAPAN TOBACCO INC. (JP) 2007-03-08 — — US disclosed
US-20060270705-A1 Method for inhibiting lipid absorption and lipid absorption inhibitor JAPAN TOBACCO INC. (JP) 2006-11-30 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070054839-A1 Method of inhibiting remnant lipoprotein production CETP, PCSK9, LIPA DUSP3 1051/4885PTPN5 1379/4885PTPN11 2706/4885
US-20110189210-A1 METHOD OF INHIBITING REMNANT LIPOPROTEIN PRODUCTION CETP, PCSK9, LIPA DUSP3 1051/4885PTPN5 1379/4885PTPN11 2706/4885
US-20060270705-A1 Method for inhibiting lipid absorption and lipid absorption inhibitor CETP, SI, LIPC DUSP3 3083/4885PTPN5 3167/4885PTPN11 4049/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.