Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.41 |
| ▸ | BCL6 | P41182 | 6/20 | 0.39 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.39 |
| ▸ | STK17B | O94768 | 1/20 | 0.38 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18995184 | 0.84 | EGFR (0.39) | EGFRERBB2BCL6PTK6STK17B | |
| SCHEMBL18995012 | 0.83 | BCL6 (0.43) | EGFRBCL6STK17BSTK17ASYK | |
| SCHEMBL15320500 | 0.77 | BCL6 (0.44) | EGFRERBB2BCL6SYKNCOR2 | |
| SCHEMBL29352285 | 0.74 | BCL6 (0.61) | BCL6STK17BSTK17ASYKNCOR2 | |
| SCHEMBL2103566 | 0.74 | BCL6 (0.59) | EGFRERBB2BCL6STK17ASYK | |
| SCHEMBL19836252 | 0.73 | VRK1 (0.34) | — | |
| SCHEMBL3973068 | 0.72 | ERBB2 (0.62) | EGFRERBB2PTK6GRM4 | |
| SCHEMBL18995069 | 0.72 | ULK1 (0.44) | STK17BSTK17ASYK | |
| SCHEMBL19527725 | 0.71 | TNIK (0.39) | EGFRERBB2STK17ASYK | |
| SCHEMBL4092866 | 0.71 | EGFR (0.63) | EGFRERBB2PTK6GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9682976-B2 | Protein kinase C inhibitors and uses thereof | RIGEL PHARMACEUTICALS, INC. (US) | 2017-06-20 | — | — | US | disclosed |