Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 6/20 | 0.38 |
| ▸ | JAK2 | O60674 | 3/20 | 0.38 |
| ▸ | TYK2 | P29597 | 3/20 | 0.38 |
| ▸ | JAK3 | P52333 | 3/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 4/20 | 0.37 |
| ▸ | ITK | Q08881 | 3/20 | 0.37 |
| ▸ | FLT3 | P36888 | 3/20 | 0.37 |
| ▸ | AURKA | O14965 | 5/20 | 0.37 |
| ▸ | KDR | P35968 | 3/20 | 0.37 |
| ▸ | PLK4 | O00444 | 2/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.37 |
| ▸ | PAK4 | O96013 | 2/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18995012 | 0.88 | BCL6 (0.43) | SCN9ASYKEGFRITKSTK17A | |
| SCHEMBL18995069 | 0.86 | ULK1 (0.44) | SYKJAK2JAK3JAK1FLT3 | |
| SCHEMBL19527748 | 0.86 | TBK1 (0.37) | TNIKSCN9ASYKEGFRITK | |
| SCHEMBL18995121 | 0.85 | NPC1 (0.47) | JAK2IKBKETBK1MAPT | |
| SCHEMBL19527724 | 0.74 | EGFR (0.40) | SYKJAK2TYK2JAK3EGFR | |
| SCHEMBL4486021 | 0.74 | PTK2 (0.50) | SYKJAK2TYK2JAK3JAK1 | |
| SCHEMBL29430454 | 0.74 | PTK2 (0.50) | SYKJAK2TYK2JAK3JAK1 | |
| SCHEMBL19836644 | 0.73 | NPC1 (0.49) | SYKEGFRAURKAKDRERBB2 | |
| SCHEMBL18995059 | 0.71 | EGFR (0.41) | SYKEGFRERBB2STK17A | |
| SCHEMBL29352285 | 0.71 | BCL6 (0.61) | SYKFLT3STK17AGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2833889-B1 | PROTEIN KINASE C INHIBITORS AND USES THEREOF | RIGEL PHARMACEUTICALS INC (US) | 2017-11-01 | — | — | EP | disclosed |