Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 10/20 | 0.47 |
| ▸ | CDK4 | P11802 | 6/20 | 0.38 |
| ▸ | CSF1R | P07333 | 2/20 | 0.38 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 2/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.38 |
| ▸ | CCND1 | P24385 | 2/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19527697 | 0.84 | SYK (0.48) | LRRK2CDK4CSF1RCDK6CCNE1 | |
| SCHEMBL15321208 | 0.77 | LRRK2 (0.40) | LRRK2CDK4CSF1RCDK1CCNB1 | |
| SCHEMBL19527748 | 0.73 | TBK1 (0.37) | FLT3 | |
| SCHEMBL19527683 | 0.71 | SYK (0.47) | — | |
| SCHEMBL17708402 | 0.70 | ALDH1A1 (0.43) | MEN1KMT2A | |
| SCHEMBL15244358 | 0.69 | FGFR3 (0.74) | — | |
| SCHEMBL2551874 | 0.69 | CSF1R (0.56) | CDK4CSF1RCDK6CCNE1CDK2 | |
| SCHEMBL3497587 | 0.68 | PRKCQ (0.50) | LRRK2CSF1RCDK1CDK2FLT3 | |
| SCHEMBL17708146 | 0.68 | ALDH1A1 (0.42) | MEN1KMT2APIK3CAMTOR | |
| SCHEMBL3494976 | 0.67 | PRKCQ (0.49) | LRRK2CSF1RCDK1CDK2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2833889-B1 | PROTEIN KINASE C INHIBITORS AND USES THEREOF | RIGEL PHARMACEUTICALS INC (US) | 2017-11-01 | — | — | EP | disclosed |
| US-9682976-B2 | Protein kinase C inhibitors and uses thereof | RIGEL PHARMACEUTICALS, INC. (US) | 2017-06-20 | — | — | US | disclosed |