Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19002100 | 0.89 | NPC1 (0.45) | KDM4EALDH1A1HPGDHTT | |
| SCHEMBL19002074 | 0.89 | LMNA (0.39) | KDM4EMAPTHTTLMNA | |
| SCHEMBL2150715 | 0.86 | KDM4E (0.44) | KDM4EMAPTTP53NTSR1ALDH1A1 | |
| SCHEMBL11833922 | 0.82 | KDM4E (0.41) | KDM4EMAPTTP53NTSR1ALDH1A1 | |
| SCHEMBL9607174 | 0.79 | KDM4E (0.42) | KDM4EMAPTALDH1A1CYP3A4TDP1 | |
| SCHEMBL5532361 | 0.79 | KDM4E (0.41) | KDM4EMAPTTP53NTSR1ALDH1A1 | |
| SCHEMBL10969020 | 0.78 | KDM4E (0.38) | KDM4EMAPTTP53NTSR1ALDH1A1 | |
| SCHEMBL8425658 | 0.78 | CYP19A1 (0.43) | KDM4EMAPTALDH1A1HPGDHTT | |
| SCHEMBL10522454 | 0.77 | MAPT (0.46) | KDM4EMAPTALDH1A1HTTCYP3A4 | |
| SCHEMBL23748196 | 0.76 | MAPT (0.42) | KDM4EMAPTTP53NTSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10799494-B2 | Combination of respiratory electron transport chain inhibitors with a cytochrome bd inhibitor | LIVERPOOL SCHOOL TROPICAL MEDICINE (GB) | 2020-10-13 | — | — | US | disclosed |
| US-20190151305-A1 | COMBINATION PRODUCT | LIVERPOOL SCHOOL TROPICAL MEDICINE (GB) | 2019-05-23 | — | — | US | disclosed |
| WO-2017103615-A1 | COMBINATION PRODUCT | LIVERPOOL SCHOOL OF TROPICAL MEDICINE (GB) | 2017-06-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10799494-B2 | Combination of respiratory electron transport chain inhibitors with a cytochrome bd inhibitor | NDUFB7, NDUFB3, NDUFB5 | KDM4E 4154/4885MAPT 1315/4885TP53 4405/4885 |
| US-20190151305-A1 | COMBINATION PRODUCT | NDUFB5, NDUFB7, NDUFB10 | KDM4E 4216/4885MAPT 1113/4885TP53 3655/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.