Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.46 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.46 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.46 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.46 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.46 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.46 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1905776 | 0.82 | ENPP2 (0.59) | MAOAMAOBSMN1; SMN2PRKAB2PRKAG1 | |
| SCHEMBL1907708 | 0.81 | OPRK1 (0.51) | SMN1; SMN2PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL9014112 | 0.77 | OPRK1 (0.53) | NPC1LMNARAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL4464631 | 0.74 | BCHE (0.65) | NPC1LMNARAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL11393297 | 0.72 | NPC1 (0.56) | NPC1LMNARAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL8480700 | 0.72 | BCHE (0.55) | NPC1LMNARAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL8480272 | 0.69 | BCHE (0.63) | MAOBACHEBCHE | |
| SCHEMBL8717826 | 0.69 | BCHE (0.60) | LMNASMN1; SMN2ACHEBCHE | |
| Hydrochloric Acid SCHEMBL9013903 | 0.69 | SMN1; SMN2 (0.58) | MAOAMAOBNPC1LMNARAB9A | |
| SCHEMBL8534498 | 0.69 | DRD4 (0.71) | ABL1RIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2316458-A1 | Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase | Xenon Pharmaceuticals Inc. (CA) | 2011-05-04 | — | — | EP | claimed |
| US-7829712-B2 | Pyridazine derivatives for inhibiting human stearoyl-CoA-desaturase | XENON PHARMACEUTICALS INC. (CA) | 2010-11-09 | — | — | US | claimed |
| US-20080207587-A1 | Pyridazine Derivatives for Inhibiting Human Stearoyl-Coa-Desaturase | XENON PHARMACEUTICALS INC. (CA) | 2008-08-28 | — | — | US | claimed |
| EP-1814551-A2 | PYRIDAZINE DERIVATIVES FOR INHIBITING HUMAN STEAROYL-COA-DESATURASE | XENON PHARMACEUTICALS INC. (CA) | 2007-08-08 | — | — | EP | claimed |
| WO-2006034341-A2 | PYRIDAZINE DERIVATIVES FOR INHIBITING HUMAN STEAROYL-COA-DESATURASE | XENON PHARMACEUTICALS INC. (CA) | 2006-03-30 | — | — | WO | claimed |
| EP-2316458-A1 | Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase | Xenon Pharmaceuticals Inc. (CA) | 2011-05-04 | — | — | EP | disclosed |
| US-7829712-B2 | Pyridazine derivatives for inhibiting human stearoyl-CoA-desaturase | XENON PHARMACEUTICALS INC. (CA) | 2010-11-09 | — | — | US | disclosed |
| US-20080207587-A1 | Pyridazine Derivatives for Inhibiting Human Stearoyl-Coa-Desaturase | XENON PHARMACEUTICALS INC. (CA) | 2008-08-28 | — | — | US | disclosed |
| EP-1814551-A2 | PYRIDAZINE DERIVATIVES FOR INHIBITING HUMAN STEAROYL-COA-DESATURASE | XENON PHARMACEUTICALS INC. (CA) | 2007-08-08 | — | — | EP | disclosed |
| WO-2006034341-A2 | PYRIDAZINE DERIVATIVES FOR INHIBITING HUMAN STEAROYL-COA-DESATURASE | XENON PHARMACEUTICALS INC. (CA) | 2006-03-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207587-A1 | Pyridazine Derivatives for Inhibiting Human Stearoyl-Coa-Desaturase | SCD, SCD5, FADS2 | MAOA 895/4885MAOB 811/4885NPC1 612/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.