Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | CRHBP | P24387 | 1/20 | 0.50 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.50 |
| ▸ | AR | P10275 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16177628 | 0.84 | TRPV4 (0.43) | CYP3A4HSD17B10HPGDCRHBPCRHR2 | |
| SCHEMBL27367025 | 0.84 | CYP3A4 (0.48) | CYP3A4HSD17B10HPGDCRHBPCRHR2 | |
| SCHEMBL952362 | 0.78 | ALDH1A1 (0.45) | CYP3A4HSD17B10HPGDMEN1ALDH1A1 | |
| SCHEMBL15850516 | 0.76 | VCAM1 (0.40) | CYP3A4HPGDARMEN1ALDH1A1 | |
| SCHEMBL1630139 | 0.74 | NMT1 (0.38) | CYP3A4HPGDMEN1ALDH1A1MAPT | |
| SCHEMBL6416771 | 0.74 | ALDH1A1 (0.38) | CYP3A4HSD17B10HPGDMEN1ALDH1A1 | |
| SCHEMBL21064821 | 0.74 | TRPV4 (0.41) | CYP3A4HSD17B10HPGDMEN1ALDH1A1 | |
| SCHEMBL21305046 | 0.74 | ALDH1A1 (0.38) | CYP3A4HPGDMEN1ALDH1A1MAPT | |
| SCHEMBL1810815 | 0.74 | CYP3A4 (0.50) | CYP3A4HPGDMEN1ALDH1A1MAPT | |
| SCHEMBL1811343 | 0.74 | ALDH1A1 (0.38) | CYP3A4HPGDMEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4282355-A | — | — | None | — | — | JP | disclosed |
| US-20150259327-A1 | Chemical Compounds | PFIZER LIMITED (GB) | 2015-09-17 | — | — | US | disclosed |
| US-9067922-B2 | Chemical compounds | PFIZER LIMITED (GB) | 2015-06-30 | — | — | US | disclosed |
| WO-2014170792-A1 | SULFONAMIDE DERIVATIVES AS URAT-1 INHIBITORS | PFIZER LIMITED (GB) | 2014-10-23 | — | — | WO | disclosed |
| US-20140315878-A1 | CHEMICAL COMPOUNDS | PFIZER LIMITED (GB) | 2014-10-23 | — | — | US | disclosed |
| US-20110112264-A1 | PROCESS FOR PRODUCING POLYMERIZATION CATALYST OF ALKYLENE OXIDE AND POLY(ALKYLENE OXIDE) | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2011-05-12 | — | — | US | disclosed |
| US-20100280197-A1 | MODIFIED PARTICLE, SUPPORT, CATALYST COMPONENT FOR ADDITION POLYMERIZATION, CATALYST FOR ADDITION POLYMERIZATION, AND PROCESS FOR PRODUCING ADDITION POLYMER | TAKAOKI KAZUO | 2010-11-04 | — | — | US | disclosed |
| US-20030069127-A1 | Modified particle,support, catalyst component for addition polymerization, catalyst for addition polymerization, and process for producing addition polymer | SUMITOMO CHEMICAL COMPANY, LIMTED (JP) | 2003-04-10 | — | — | US | disclosed |
| EP-1275662-A1 | MODIFIED PARTICLE, SUPPORT, CATALYST COMPONENT FOR ADDITION POLYMERIZATION, CATALYST FOR ADDITION POLYMERIZATION, AND PROCESS FOR PRODUCING ADDITION POLYMER | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2003-01-15 | — | — | EP | disclosed |
| EP-1150565-A1 | THIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | LION bioscience AG (DE) | 2001-11-07 | — | — | EP | disclosed |
| WO-2000045635-A1 | THIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | LION BIOSCIENCE AG (DE) | 2000-08-10 | — | — | WO | disclosed |
| JP-H04282355-A | DICHLORO CYANO COMPOUND, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL ELECTROOPTICAL ELEMENT | SEIMI CHEM KK | 1992-10-07 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150259327-A1 | Chemical Compounds | SULT2A1, SULT1A1, SULT1E1 | CYP3A4 1604/4885HSD17B10 2398/4885HPGD 4483/4885 |
| US-20140315878-A1 | CHEMICAL COMPOUNDS | SULT2A1, SULT1A1, SULT1E1 | CYP3A4 1604/4885HSD17B10 2398/4885HPGD 4483/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.