Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 4/20 | 0.73 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.73 |
| ▸ | PTAFR | P25105 | 2/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.54 |
| ▸ | DRD3 | P35462 | 2/20 | 0.54 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | HTR3A | P46098 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | GHSR | Q92847 | 1/20 | 0.53 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.49 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.49 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.49 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.49 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11829115 | 0.89 | OPRK1 (0.57) | OPRK1PDE4DPTAFRCYP3A4DRD3 | |
| SCHEMBL11829109 | 0.89 | OPRK1 (0.57) | OPRK1PDE4DPTAFRCYP3A4DRD3 | |
| SCHEMBL7435143 | 0.88 | OPRK1 (0.76) | OPRK1PDE4DPTAFRGABRA1GABRA5 | |
| SCHEMBL11183101 | 0.86 | PTAFR (0.60) | OPRK1PDE4DPTAFRCYP3A4DRD3 | |
| Estazolam SCHEMBL28766 | 0.84 | OPRK1 (1.00) | OPRK1PDE4DKCNH2GABRA1GABRA5 | |
| Estazolam SCHEMBL29357458 | 0.84 | OPRK1 (1.00) | OPRK1PDE4DKCNH2GABRA1GABRA5 | |
| Midazolam SCHEMBL5677486 | 0.83 | OPRK1 (0.73) | OPRK1PDE4DPTAFRCYP3A4DRD3 | |
| SCHEMBL11824259 | 0.82 | CYP3A4 (0.53) | OPRK1PDE4DPTAFRCYP3A4DRD3 | |
| SCHEMBL11824262 | 0.82 | CYP3A4 (0.53) | OPRK1PDE4DPTAFRCYP3A4DRD3 | |
| SCHEMBL11729005 | 0.81 | OPRK1 (0.57) | OPRK1PDE4DPTAFRCYP3A4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180312511-A1 | SHORT-ACTING BENZODIAZEPINE DERIVATIVES, PREPARATION METHOD THEREFOR, AND USE THEREOF | SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD. (CN) | 2018-11-01 | — | — | US | disclosed |
| EP-3363801-A1 | SHORT-ACTING BENZODIAZEPINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. (CN) | 2018-08-22 | — | — | EP | disclosed |
| WO-2017101808-A1 | SHORT-ACTING BENZODIAZEPINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2017-06-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180312511-A1 | SHORT-ACTING BENZODIAZEPINE DERIVATIVES, PREPARATION METHOD THEREFOR, AND USE THEREOF | GABRA5, GABRA1, GABRA6 | OPRK1 47/4885PDE4D 915/4885PTAFR 2089/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.