Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Midazolam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 known ✓ | P14867 | 3/20 | 0.54 |
| ▸ | GABRA5 known ✓ | P31644 | 3/20 | 0.54 |
| ▸ | GABRA2 known ✓ | P47869 | 3/20 | 0.54 |
| ▸ | GABRA3 known ✓ | P34903 | 2/20 | 0.54 |
| ▸ | GABRB2 known ✓ | P47870 | 2/20 | 0.54 |
| ▸ | GABRG2 known ✓ | P18507 | 1/20 | 0.47 |
| ▸ | GABRB3 known ✓ | P28472 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.73 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.73 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.73 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.73 |
| ▸ | DRD3 | P35462 | 1/20 | 0.73 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | BRD4 | O60885 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | CNR1 | P21554 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | PTAFR | P25105 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Midazolam SCHEMBL5783371 | 0.85 | OPRK1 (1.00) | OPRK1PDE4DCYP3A4SLC22A1ABCB11 | |
| Midazolam SCHEMBL29357425 | 0.85 | OPRK1 (1.00) | OPRK1PDE4DCYP3A4SLC22A1ABCB11 | |
| Midazolam SCHEMBL29480459 | 0.85 | OPRK1 (1.00) | OPRK1PDE4DCYP3A4SLC22A1ABCB11 | |
| Midazolam SCHEMBL35061 | 0.85 | OPRK1 (1.00) | OPRK1PDE4DCYP3A4SLC22A1ABCB11 | |
| Midazolam SCHEMBL29735381 | 0.85 | OPRK1 (1.00) | OPRK1PDE4DCYP3A4SLC22A1ABCB11 | |
| Midazolam SCHEMBL29565146 | 0.85 | OPRK1 (1.00) | OPRK1PDE4DCYP3A4SLC22A1ABCB11 | |
| Midazolam SCHEMBL1311204 | 0.84 | OPRK1 (0.98) | OPRK1PDE4DCYP3A4SLC22A1ABCB11 | |
| Midazolam SCHEMBL41265 | 0.84 | OPRK1 (0.98) | OPRK1PDE4DCYP3A4SLC22A1ABCB11 | |
| Midazolam SCHEMBL29445200 | 0.84 | OPRK1 (0.98) | OPRK1PDE4DCYP3A4SLC22A1ABCB11 | |
| Midazolam SCHEMBL29419655 | 0.84 | OPRK1 (0.98) | OPRK1PDE4DCYP3A4SLC22A1ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7018619-B2 | Delivery of alprazolam, estazolam midazolam or triazolam through an inhalation route | ALEXZA PHARMACEUTICALS, INC. (US) | 2006-03-28 | — | — | US | disclosed |
| US-20040127490-A1 | Delivery of alprazolam, estazolam midazolam or triazolam through an inhalation route | ALEXZA MOLECULAR DELIVERY CORPORATION | 2004-07-01 | — | — | US | disclosed |