Sugi Predict

Sugi Predict / Compounds / SCHEMBL190224

SCHEMBL190224

SCHEMBL190224

COC(=O)c1cccc(S)c1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TSHR P16473 2/20 0.57
▸ LOXL2 Q9Y4K0 1/20 0.56
▸ CYP4F2 P78329 2/20 0.54
▸ CYP4A11 Q02928 2/20 0.54
▸ RAB9A P51151 3/20 0.53
▸ POLB P06746 1/20 0.53
▸ ALDH1A1 P00352 2/20 0.51
▸ NPC1 O15118 2/20 0.50
▸ CA12 O43570 2/20 0.50
▸ CA1 P00915 2/20 0.50
▸ CA2 P00918 2/20 0.50
▸ CA9 Q16790 2/20 0.50
▸ CA7 P43166 1/20 0.50
▸ XDH P47989 1/20 0.50
▸ CA14 Q9ULX7 1/20 0.50
▸ TP53 P04637 3/20 0.47
▸ SMN1; SMN2 Q16637 1/20 0.47
▸ MAPT P10636 1/20 0.47
▸ SLC7A5 Q01650 1/20 0.47
▸ LMNA P02545 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Methane SCHEMBL28670470 0.98 TSHR (0.55) TSHRLOXL2CYP4F2CYP4A11RAB9A
SCHEMBL10421108 0.93 TSHR (0.50) TSHRLOXL2CYP4F2CYP4A11RAB9A
SCHEMBL10421481 0.88 TSHR (0.53) TSHRLOXL2CYP4F2CYP4A11RAB9A
SCHEMBL34953 0.85 TSHR (0.70) TSHRLOXL2CYP4F2CYP4A11RAB9A
SCHEMBL7907753 0.85 TSHR (0.50) TSHRLOXL2CYP4F2CYP4A11RAB9A
SCHEMBL10941453 0.83 TSHR (0.67) TSHRLOXL2CYP4F2CYP4A11RAB9A
SCHEMBL9943503 0.83 TSHR (0.67) TSHRLOXL2CYP4F2CYP4A11RAB9A
SCHEMBL29966404 0.83 TSHR (0.67) TSHRLOXL2CYP4F2CYP4A11RAB9A
Potassium SCHEMBL30190417 0.83 TSHR (0.67) TSHRLOXL2CYP4F2CYP4A11RAB9A
Ammonia Solution, Strong SCHEMBL28556515 0.83 TSHR (0.67) TSHRLOXL2CYP4F2CYP4A11RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 265 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118562273-A Long glass fiber reinforced polycarbonate and preparation method thereof 万华化学（宁波）有限公司 2024-08-30 — — CN claimed
US-4113495-A 2,4,4-TRIMETHYL-2-(2,5-DIHYDROXYPHENYL)-6-HYDROXY-CHROMANS FUJI PHOTO FILM CO., LTD. (JP) 1978-09-12 — — US claimed
US-12383560-B2 Compounds and uses thereof FOGHORN THERAPEUTICS INC. (US) 2025-08-12 — — US disclosed
US-20250179000-A1 METABOTROPIC GLUTAMATE RECEPTOR POSITIVE ALLOSTERIC MODULATORS (PAMS) AND USES THEREOF Sanford Burnham Prebys Medical Discovery Institute 2025-06-05 — — US disclosed
EP-4452918-A1 METABOTROPIC GLUTAMATE RECEPTOR POSITIVE ALLOSTERIC MODULATORS (PAMS) AND USES THEREOF Sanford Burnham Prebys Medical Discovery Institute (US) 2024-10-30 — — EP disclosed
CN-118562273-A Long glass fiber reinforced polycarbonate and preparation method thereof 万华化学（宁波）有限公司 2024-08-30 — — CN disclosed
US-11919921-B2 Galactoside inhibitor of galectins GALECTO BIOTECH AB (DK) 2024-03-05 — — US disclosed
US-11827640-B2 Substituted pyrazolo[1,5-a]pyrimidines as CFTR modulators ILDONG PHARMACEUTICAL CO., LTD. (KR) 2023-11-28 — — US disclosed
US-20230310445-A1 LOX ENZYME INHIBITING METHODS AND COMPOSITIONS ANOVIA BIOSCIENCES, INC. 2023-10-05 — — US disclosed
US-20230310445-A1 LOX ENZYME INHIBITING METHODS AND COMPOSITIONS ANOVIA BIOSCIENCES, INC. 2023-10-05 — — US disclosed
US-20230310445-A1 LOX ENZYME INHIBITING METHODS AND COMPOSITIONS ANOVIA BIOSCIENCES, INC. 2023-10-05 — — US disclosed
US-RE33300-E LEUKOTRIENE ANTAGONISTS; ANTIALLERGENS ELI LILLY AND COMPANY (US) 1990-08-14 — — US disclosed
US-4839272-A IMPROVED MAGENTA DYE-PROVIDING SUBSTANCES FUJI PHOTO FILM CO., LTD. (JP) 1989-06-13 — — US disclosed
EP-0318093-A2 Diarylquinoline diacids and their use as medicaments MERCK FROSST CANADA INC. (CA) 1989-05-31 — — EP disclosed
EP-0134111-B1 ARALIPHATIC SULPHIDES,SULPHONES AND SULPHOXIDES AND THEIR PHARMACEUTICAL USE Lilly Industries Limited (GB) 1988-12-07 — — EP disclosed
US-4782004-A PHENOLIC SULFONAMIDE OR POLYMER WITH PHENOL AND/OR SULFONAMIDE GROUPS FUJI PHOTO FILM CO., LTD. (JP) 1988-11-01 — — US disclosed
US-4670465-A ANTIINFLAMMATORY AGENTS SYNTEX (U.S.A.) INC. (US) 1987-06-02 — — US disclosed
US-4665189-A LEUKOTRIENE ANTAGONISTS LILLY INDUSTRIES LIMITED (GB) 1987-05-12 — — US disclosed
EP-0201823-A2 Novel intermediates for the production of pharmaceuticals LILLY INDUSTRIES LIMITED (GB) 1986-11-20 — — EP disclosed
EP-0134111-A1 Araliphatic sulphides,sulphones and sulphoxides and their pharmaceutical use Lilly Industries Limited (GB) 1985-03-13 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11827640-B2 Substituted pyrazolo[1,5-a]pyrimidines as CFTR modulators PDE4A, PDE4B, PDE5A TSHR 2647/4885LOXL2 3971/4885CYP4F2 1510/4885
US-20230310445-A1 LOX ENZYME INHIBITING METHODS AND COMPOSITIONS LOX, LOXL1, LOXL2 TSHR 4171/4885LOXL2 3/4885CYP4F2 1351/4885
US-11919921-B2 Galactoside inhibitor of galectins LGALS3, LGALS1, LGALS2 TSHR 1149/4885LOXL2 1034/4885CYP4F2 3740/4885
US-20250179000-A1 METABOTROPIC GLUTAMATE RECEPTOR POSITIVE ALLOSTERIC MODULATORS (PAMS) AND USES THEREOF GRM3, GRM2, GRM1 TSHR 565/4885LOXL2 3959/4885CYP4F2 4184/4885
US-12383560-B2 Compounds and uses thereof VHL, CLN6, TFEB TSHR 4351/4885LOXL2 2917/4885CYP4F2 2084/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.