Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | SCN1A | P35498 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3387923 | 0.76 | ALDH1A1 (0.42) | ALDH1A1MAPK1CYP1A2CHRM2CHRM1 | |
| SCHEMBL197295 | 0.76 | GLA (0.42) | ALDH1A1LMNAKDM4ESMN1; SMN2KEAP1 | |
| SCHEMBL474810 | 0.74 | ALDH1A1 (0.51) | ALDH1A1MAPK1CYP1A2CHRM2CHRM1 | |
| SCHEMBL18672765 | 0.73 | ALDH1A1 (0.44) | ALDH1A1MAPK1CYP1A2CHRM2CHRM1 | |
| SCHEMBL81823 | 0.73 | TDP1 (0.56) | ALDH1A1MAPK1CYP1A2CHRM2CHRM1 | |
| SCHEMBL14524633 | 0.72 | ALDH1A1 (0.50) | ALDH1A1MAPK1CYP1A2CHRM2CHRM1 | |
| Bromide SCHEMBL2354924 | 0.72 | ALDH1A1 (0.50) | ALDH1A1MAPK1CYP1A2CHRM2CHRM1 | |
| SCHEMBL3305244 | 0.72 | ALDH1A1 (0.54) | ALDH1A1MAPK1CYP1A2CHRM2CHRM1 | |
| SCHEMBL111438 | 0.72 | TSHR (0.58) | ALDH1A1MAPK1CYP1A2CHRM2CHRM1 | |
| SCHEMBL19035795 | 0.72 | ATM (0.42) | ALDH1A1MAPK1CYP1A2CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1474420-A1 | QUINAZOLINE COMPOUNDS | Astrazeneca AB (SE) | 2004-11-10 | — | — | EP | disclosed |
| WO-2003064413-A1 | QUINAZOLINE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-08-07 | — | — | WO | disclosed |
| EP-1311500-A2 | INDOLE, AZAINDOLE AND INDAZOLE DERIVATIVES HAVING VEGF INHIBITING ACTIVITY | AstraZeneca AB (SE) | 2003-05-21 | — | — | EP | disclosed |
| WO-2002012227-A2 | INDOLE, AZAINDOLE AND INDAZOLE DERIVATIVES HAVING VEGF INHIBITING ACTIVITY | ASTRAZENECA AB (SE) | 2002-02-14 | — | — | WO | disclosed |