Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YTHDC1 | Q96MU7 | 6/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.31 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.31 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.31 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15075726 | 0.74 | POLB (0.57) | TRPA1KMT2AMEN1ALDH1A1POLB | |
| SCHEMBL20079645 | 0.69 | CYP11B2 (0.44) | YTHDC1FLT1KDRKMT2AMEN1 | |
| SCHEMBL19036437 | 0.68 | ALDH1A1 (0.58) | YTHDC1TDP1KMT2AMEN1ALDH1A1 | |
| SCHEMBL10394340 | 0.67 | GAA (0.54) | YTHDC1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL19036473 | 0.67 | YTHDC1 (0.44) | YTHDC1RAB9ADRD2DRD4DRD3 | |
| SCHEMBL20079722 | 0.66 | YTHDC1 (0.45) | YTHDC1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL19036600 | 0.66 | YTHDC1 (0.37) | YTHDC1RAB9A | |
| SCHEMBL9010469 | 0.64 | IKBKB (0.36) | YTHDC1HDAC1HDAC2RAB9A | |
| SCHEMBL18175167 | 0.64 | LMNA (0.37) | YTHDC1 | |
| SCHEMBL20079775 | 0.63 | PTGS2 (0.43) | KMT2AMEN1ALDH1A1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3184527-A1 | 2,6-DIOXO,-2,3-DIHYDRO-1H-PURINE COMPOUNDS USEFUL FOR TREATING DISORDERS RELATED TO THE ACTIVITY OF THE TRPA1 CHANNEL | Hydra Biosciences, Inc. (US) | 2017-06-28 | — | — | EP | disclosed |