⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26599287 | 0.88 | CHRNB2 (0.35) | — | |
| SCHEMBL13611642 | 0.72 | ADRB2 (0.46) | — | |
| SCHEMBL29341632 | 0.68 | ALDH1A1 (0.37) | — | |
| SCHEMBL5753333 | 0.67 | — | — | |
| SCHEMBL15647482 | 0.63 | LMNA (0.34) | — | |
| SCHEMBL26566637 | 0.61 | INMT (0.44) | — | |
| SCHEMBL4757712 | 0.60 | — | — | |
| SCHEMBL161377 | 0.60 | — | — | |
| SCHEMBL17081031 | 0.59 | — | — | |
| SCHEMBL960885 | 0.59 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1540329-A4 | DRUG DISCOVERY METHOD | KEDDEM BIO SCIENCE LTD (IL) | 2009-06-10 | — | — | EP | claimed |
| JP-2006507480-A | — | — | 2006-03-02 | — | — | JP | claimed |
| EP-1540329-A1 | DRUG DISCOVERY METHOD | KEDDEM BIO-SCIENCE LTD. (IL) | 2005-06-15 | — | — | EP | claimed |
| WO-2004010136-A1 | DRUG DISCOVERY METHOD | KEDDEM BIO-SCIENCE LTD. (IL) | 2004-01-29 | — | — | WO | claimed |
| US-5482933-A | ANOXIA, ISCHEMIA | G. D. SEARLE & CO. (US) | 1996-01-09 | — | — | US | claimed |
| US-5302586-A | Antiischemic and -hypoxia agents, particularly after a stroke, cardiac arrest, hypoglycemia or perinatal asphxia | G. D. SEARLE & CO. (US) | 1994-04-12 | — | — | US | claimed |
| EP-0163240-A2 | Dihydroimidazo[1,2-a]pyrimidine derivatives, methods of preparing said compounds and pharmaceutical compositions constaining said compounds | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1985-12-04 | — | — | EP | claimed |
| US-20240199609-A1 | COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2 | NOVARTIS AG (CH) | 2024-06-20 | — | — | US | disclosed |
| US-11905283-B2 | Compounds and compositions for inhibiting the activity of SHP2 | NOVARTIS AG (CH) | 2024-02-20 | — | — | US | disclosed |
| US-20160314241-A1 | DRUG DISCOVERY METHOD | Keddem Bioscience Ltd. (IL) | 2016-10-27 | — | — | US | disclosed |
| US-20160314241-A1 | DRUG DISCOVERY METHOD | Keddem Bioscience Ltd. (IL) | 2016-10-27 | — | — | US | disclosed |
| US-20160314241-A1 | DRUG DISCOVERY METHOD | Keddem Bioscience Ltd. (IL) | 2016-10-27 | — | — | US | disclosed |
| US-9405885-B2 | Drug discovery method | Keddem Bioscience Ltd. (IL) | 2016-08-02 | — | — | US | disclosed |
| US-5302586-A | Antiischemic and -hypoxia agents, particularly after a stroke, cardiac arrest, hypoglycemia or perinatal asphxia | G. D. SEARLE & CO. (US) | 1994-04-12 | — | — | US | disclosed |
| US-5252563-A | 5,6,7,8-tetrahydro-imidazo[1,2-a]pyrimidine compounds for treatment of neurotoxic injury | G. D. SEARLE & COMPANY (US) | 1993-10-12 | — | — | US | disclosed |
| US-5252563-A | 5,6,7,8-tetrahydro-imidazo[1,2-a]pyrimidine compounds for treatment of neurotoxic injury | G. D. SEARLE & COMPANY (US) | 1993-10-12 | — | — | US | disclosed |
| EP-0163240-A3 | Dihydroimidazo[1,2-a]pyrimidine derivatives, methods of preparing said compounds and pharmaceutical compositions constaining said compounds | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1987-04-22 | — | — | EP | disclosed |
| EP-0183848-A1 | POLYAZAHETEROCYCLIC DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITION | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1986-06-11 | — | — | EP | disclosed |
| EP-0163240-A2 | Dihydroimidazo[1,2-a]pyrimidine derivatives, methods of preparing said compounds and pharmaceutical compositions constaining said compounds | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1985-12-04 | — | — | EP | disclosed |
| EP-0163240-A2 | Dihydroimidazo[1,2-a]pyrimidine derivatives, methods of preparing said compounds and pharmaceutical compositions constaining said compounds | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1985-12-04 | — | — | EP | disclosed |