Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.48 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | GAA | P10253 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HTR3A | P46098 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2453453 | 0.84 | MAPT (0.59) | MAPTMEN1KMT2AALDH1A1GAA | |
| SCHEMBL21222876 | 0.81 | DRD2 (0.55) | MAPTMEN1KMT2AALDH1A1GAA | |
| SCHEMBL29914647 | 0.81 | DRD2 (0.55) | MAPTMEN1KMT2AALDH1A1GAA | |
| SCHEMBL4649484 | 0.79 | HTR3A (0.69) | MAPTMEN1KMT2AALDH1A1GAA | |
| SCHEMBL25340124 | 0.79 | POLB (0.47) | MAPTMEN1KMT2AALDH1A1GAA | |
| SCHEMBL30749598 | 0.78 | LRRK2 (0.51) | MAPTMEN1KMT2AALDH1A1GAA | |
| SCHEMBL27170833 | 0.78 | LRRK2 (0.51) | MAPTMEN1KMT2AALDH1A1GAA | |
| SCHEMBL12675649 | 0.77 | ERN1 (0.48) | GAAPOLB | |
| SCHEMBL25337128 | 0.76 | POLB (0.47) | MAPTMEN1KMT2AALDH1A1GAA | |
| SCHEMBL7723267 | 0.75 | TERT (0.55) | MAPTMEN1KMT2AALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2496230-A1 | IRE-1 ALPHA INHIBITORS | MannKind Corporation (US) | 2012-09-12 | — | — | EP | disclosed |
| WO-2011056744-A1 | IRE-1 α INHIBITORS | MANNKIND CORPORATION (US) | 2011-05-12 | — | — | WO | disclosed |