Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.55 |
| ▸ | CHKA | P35790 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.35 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28094583 | 0.90 | CA2 (0.46) | CA2CHKAPOLBCA12CA1 | |
| SCHEMBL5320124 | 0.85 | ALDH1A1 (0.48) | CA2CHKAALDH1A1POLBHSD11B1 | |
| SCHEMBL28214835 | 0.82 | CA2 (0.36) | CA2CHKAPOLBCA12CA1 | |
| SCHEMBL29437665 | 0.79 | CA2 (0.65) | CA2CHKAALDH1A1POLBCA12 | |
| SCHEMBL5875153 | 0.73 | CA2 (0.41) | CA2CHKACA12CA1CA9 | |
| SCHEMBL5874622 | 0.73 | CA2 (0.41) | CA2CHKACA12CA1CA9 | |
| SCHEMBL25218195 | 0.72 | CA2 (0.42) | CA2CHKAALDH1A1POLBHSD11B1 | |
| SCHEMBL23152129 | 0.72 | CA2 (0.50) | CA2CHKAALDH1A1POLBCA12 | |
| SCHEMBL3175235 | 0.72 | CA2 (1.00) | CA2CHKAALDH1A1CA12CA1 | |
| SCHEMBL4958163 | 0.72 | CA2 (0.39) | CA2CHKAALDH1A1POLBCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024099395-A1 | COMPOUNDS FOR THE DEGRADATION OF EGFR KINASE | BEIGENE, LTD. (KY) | 2024-05-16 | — | — | WO | disclosed |
| EP-4225749-A1 | COMPOUNDS AND METHODS OF TREATING CANCERS | Cullgen (Shanghai), Inc. (CN) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022100710-A1 | TYROSINE KINASE 2 (TYK2) DEGRADATION COMPOUNDS AND METHODS OF USE | CULLGEN (SHANGHAI) , INC. (CN) | 2022-05-19 | — | — | WO | disclosed |
| WO-2022073469-A1 | COMPOUNDS AND METHODS OF TREATING CANCERS | CULLGEN (SHANGHAI) , INC. (CN) | 2022-04-14 | — | — | WO | disclosed |
| WO-2022012622-A1 | DEGRADATION OF (EGFR) BY CONJUGATION OF EGFR INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | BEIGENE, LTD. (KY) | 2022-01-20 | — | — | WO | disclosed |
| WO-2017114351-A1 | CERTAIN PROTEIN KINASE INHIBITORS | Chongqing Fochon Pharmaceutical Co., Ltd. (CN) | 2017-07-06 | — | — | WO | disclosed |