Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | CHKA | P35790 | 1/20 | 0.50 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PADI1 | Q9ULC6 | 1/20 | 0.36 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.36 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.34 |
| ▸ | F2R | P25116 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14163283 | 0.87 | ALDH1A1 (0.44) | ALDH1A1POLBTHRBATML3MBTL1 | |
| SCHEMBL28762420 | 0.77 | CHRM5 (0.40) | CA2CHKACHRM5CHRM3SIGMAR1 | |
| SCHEMBL29010574 | 0.75 | CHRM5 (0.39) | CA2CHKACHRM5CHRM3SIGMAR1 | |
| SCHEMBL29437665 | 0.75 | CA2 (0.65) | CA2CHKASIGMAR1ALDH1A1POLB | |
| SCHEMBL28762422 | 0.73 | MEN1 (0.39) | CA2CHRM5CHRM3SIGMAR1ALDH1A1 | |
| SCHEMBL1143951 | 0.73 | TSHR (0.50) | CA2CHKAALDH1A1POLBTHRB | |
| SCHEMBL28965503 | 0.72 | ITGB3 (0.58) | CA2CHKACHRM3ALDH1A1THRB | |
| Hydrochloric Acid SCHEMBL27453248 | 0.72 | CHRM5 (0.41) | CA2CHRM5CHRM3SIGMAR1ALDH1A1 | |
| SCHEMBL254801 | 0.72 | GAA (0.67) | CA2CHKACHRM5CHRM3SIGMAR1 | |
| SCHEMBL19066161 | 0.72 | CA2 (0.55) | CA2CHKAALDH1A1POLBCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024120442-A1 | PAK4 PROTEIN DEGRADERS, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS | CONVERGEN (SUZHOU) PHARMACEUTICAL CO., LTD. (CN) | 2024-06-13 | — | — | WO | disclosed |
| WO-2022143856-A1 | DEGRADATION OF BRUTON'S TYROSINE KINASE (BTK) BY CONJUGATION OF BTK INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | BEIGENE, LTD. (KY) | 2022-07-07 | — | — | WO | disclosed |
| WO-2021058017-A1 | DEGRADATION OF ANDROGEN RECEPTOR (AR) BY CONJUGATION OF AR ANTAGONISTS WITH E3 LIGASE LIGAND AND METHODS OF USE | BEIGENE, LTD. (KY) | 2021-04-01 | — | — | WO | disclosed |