Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ICMT | O60725 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | GALR3 | O60755 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SNCA | P37840 | 2/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28665118 | 0.71 | CDC25A (0.58) | POLBMEN1KMT2AICMTCNR2 | |
| SCHEMBL5154462 | 0.71 | KMT2A (0.42) | POLBMEN1KMT2AICMTUSP2 | |
| SCHEMBL17176648 | 0.70 | RAB9A (0.64) | POLBMEN1KMT2ACNR2HTR3A | |
| SCHEMBL4601912 | 0.68 | SCN9A (0.50) | POLBMEN1KMT2AUSP2TSHR | |
| SCHEMBL28247078 | 0.67 | PRMT5 (0.48) | POLBMEN1KMT2AICMTUSP2 | |
| SCHEMBL17170689 | 0.67 | TSHR (0.67) | POLBMEN1KMT2ATSHRCNR2 | |
| SCHEMBL21600839 | 0.66 | MEN1 (0.47) | POLBMEN1KMT2ATSHRCNR2 | |
| SCHEMBL29277385 | 0.66 | POLB (0.60) | POLBMEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL10244867 | 0.64 | CYP19A1 (0.50) | MEN1KMT2AICMTUSP2TSHR | |
| SCHEMBL11712972 | 0.64 | MEN1 (0.45) | POLBMEN1KMT2ATSHRCNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9695195-B2 | 5-HT3 receptor antagonists | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2017-07-04 | — | — | US | disclosed |