Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 12/20 | 0.74 |
| ▸ | PDE4A | P27815 | 11/20 | 0.74 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.74 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.74 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19075717 | 0.90 | PDE4A (0.74) | PDE4DPDE4APDE4BPDE4CEPHX2 | |
| SCHEMBL19075747 | 0.89 | PDE4A (0.61) | PDE4DPDE4APDE4BPDE4CEPHX2 | |
| SCHEMBL20697634 | 0.87 | PDE4A (0.58) | PDE4DPDE4APDE4BPDE4CEPHX2 | |
| SCHEMBL7423009 | 0.86 | PDE4D (0.76) | PDE4DPDE4APDE4BPDE4CEPHX2 | |
| SCHEMBL7477234 | 0.85 | PDE4D (0.82) | PDE4DPDE4APDE4BPDE4CEPHX2 | |
| SCHEMBL8947287 | 0.84 | KMT2A (0.76) | PDE4DPDE4APDE4BPDE4CMEN1 | |
| SCHEMBL7458162 | 0.83 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4CEPHX2 | |
| SCHEMBL7364684 | 0.80 | PDE4D (0.60) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL20805930 | 0.80 | FAAH (0.58) | PDE4DPDE4APDE4BPDE4CEPHX2 | |
| SCHEMBL8342920 | 0.79 | PDE4D (0.62) | PDE4DPDE4APDE4BPDE4CEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11149002-B2 | Therapeutic compounds and methods of use thereof | GENENTECH, INC. (US) | 2021-10-19 | — | — | US | disclosed |
| US-20210078947-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2021-03-18 | — | — | US | disclosed |
| US-20190031607-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2019-01-31 | — | — | US | disclosed |
| US-10005724-B2 | Therapeutic compounds and methods of use thereof | GENENTECH, INC. (US) | 2018-06-26 | — | — | US | disclosed |
| US-20170190662-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2017-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170190662-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | RDX, C1R, MTX1 | PDE4D 461/4885PDE4A 449/4885PDE4B 452/4885 |
| US-11149002-B2 | Therapeutic compounds and methods of use thereof | RDX, C1R, MTX1 | PDE4D 461/4885PDE4A 449/4885PDE4B 452/4885 |
| US-20190031607-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | RDX, C1R, MTX1 | PDE4D 461/4885PDE4A 449/4885PDE4B 452/4885 |
| US-10005724-B2 | Therapeutic compounds and methods of use thereof | RDX, C1R, MTX1 | PDE4D 461/4885PDE4A 449/4885PDE4B 452/4885 |
| US-20210078947-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | RDX, C1R, MTX1 | PDE4D 461/4885PDE4A 449/4885PDE4B 452/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.