Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 15/20 | 0.57 |
| ▸ | AGXT | P21549 | 9/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | MAOA | P21397 | 4/20 | 0.44 |
| ▸ | MAOB | P27338 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12482566 | 0.83 | NOS1 (0.48) | MAOAMAOB | |
| SCHEMBL2559404 | 0.79 | SOD1 (0.51) | MAOAMAOB | |
| SCHEMBL14241526 | 0.79 | MAOB (0.42) | MAOAMAOB | |
| SCHEMBL29952223 | 0.79 | TSHR (0.53) | MAOAMAOB | |
| SCHEMBL8162423 | 0.78 | ALDH1A1 (0.51) | CYP3A4MAOAMAOB | |
| SCHEMBL13357758 | 0.78 | PPARD (0.47) | — | |
| SCHEMBL1246024 | 0.77 | CYP4F2 (0.61) | MAOAMAOB | |
| SCHEMBL13477536 | 0.75 | PPARA (0.57) | IDO1AGXT | |
| SCHEMBL513678 | 0.75 | CYP3A4 (0.58) | CYP3A4MAOAMAOB | |
| SCHEMBL2727598 | 0.75 | CHRNB2 (0.50) | CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10016410-B2 | Tetrahydroisoquinolin-1-one derivative or salt thereof | SELDAR PHARMA INC. (US) | 2018-07-10 | — | — | US | disclosed |
| US-20170189390-A1 | TETRAHYDROISOQUINOLIN-1-ONE DERIVATIVE OR SALT THEREOF | SELDAR PHARMA INC. (US) | 2017-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170189390-A1 | TETRAHYDROISOQUINOLIN-1-ONE DERIVATIVE OR SALT THEREOF | BRS3, BDKRB2, NTSR2 | IDO1 1364/4885AGXT 4231/4885CYP3A4 3909/4885 |
| US-10016410-B2 | Tetrahydroisoquinolin-1-one derivative or salt thereof | BRS3, BDKRB2, NTSR2 | IDO1 1364/4885AGXT 4231/4885CYP3A4 3909/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.