SCHEMBL19085979 — predicted protein targets

Predicted protein targets (top 11)

	gene	UniProt	supporting neighbours	confidence
▸	MAOB	P27338	4/20	0.41

▸	ROCK2	O75116	5/20	0.39

▸	ROCK1	Q13464	4/20	0.39

▸	PRMT5	O14744	4/20	0.38

▸	WDR77	Q9BQA1	4/20	0.38

▸	METTL3	Q86U44	1/20	0.37

▸	NAMPT	P43490	2/20	0.36

▸	AKT1	P31749	1/20	0.36

▸	MAOA	P21397	1/20	0.36

▸	KDM1A	O60341	3/20	0.35

▸	HDAC6	Q9UBN7	3/20	0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL19085992	0.93	PRMT5 (0.40)	ROCK2ROCK1PRMT5WDR77METTL3
SCHEMBL19085997	0.93	PRMT5 (0.40)	ROCK2ROCK1PRMT5WDR77METTL3
SCHEMBL19086003	0.89	METTL3 (0.38)	MAOBROCK2ROCK1PRMT5WDR77
SCHEMBL19085985	0.89	PRMT5 (0.40)	ROCK2ROCK1PRMT5WDR77METTL3
SCHEMBL19085994	0.88	ROCK2 (0.41)	MAOBROCK2ROCK1PRMT5WDR77
SCHEMBL19086986	0.87	PRMT5 (0.38)	MAOBROCK2ROCK1PRMT5WDR77
SCHEMBL19086260	0.87	METTL3 (0.38)	MAOBROCK2ROCK1PRMT5WDR77
SCHEMBL19086023	0.87	NAMPT (0.38)	MAOBROCK2ROCK1PRMT5WDR77
SCHEMBL19086036	0.86	ROCK2 (0.37)	MAOBROCK2ROCK1PRMT5WDR77
SCHEMBL19086043	0.86	MAOB (0.36)	MAOBROCK2ROCK1PRMT5WDR77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2017114275-A1	COMPOUND FOR INHIBITING ROCK, PREPARATION METHOD AND USE OF SAME	成都先导药物开发有限公司	2017-07-06	—	—	WO	disclosed