SCHEMBL19086260 — predicted protein targets

Predicted protein targets (top 10)

	gene	UniProt	supporting neighbours	confidence
▸	METTL3	Q86U44	1/20	0.38

▸	PRMT5	O14744	11/20	0.36

▸	WDR77	Q9BQA1	11/20	0.36

▸	MAOB	P27338	1/20	0.34

▸	NAMPT	P43490	2/20	0.34

▸	ANPEP	P15144	1/20	0.34

▸	ROCK2	O75116	1/20	0.34

▸	ROCK1	Q13464	1/20	0.34

▸	BTK	Q06187	1/20	0.33

▸	DDR1	Q08345	2/20	0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL19085997	0.90	PRMT5 (0.40)	METTL3PRMT5WDR77NAMPTROCK2
SCHEMBL19085992	0.90	PRMT5 (0.40)	METTL3PRMT5WDR77NAMPTROCK2
SCHEMBL19086003	0.89	METTL3 (0.38)	METTL3PRMT5WDR77MAOBNAMPT
SCHEMBL19086994	0.89	MAOB (0.39)	METTL3PRMT5WDR77MAOBNAMPT
SCHEMBL19086205	0.89	MAOB (0.39)	METTL3PRMT5WDR77MAOBNAMPT
SCHEMBL19085985	0.89	PRMT5 (0.40)	METTL3PRMT5WDR77ROCK2ROCK1
SCHEMBL19086251	0.88	METTL3 (0.39)	METTL3PRMT5WDR77MAOBROCK2
SCHEMBL19086986	0.87	PRMT5 (0.38)	METTL3PRMT5WDR77MAOBNAMPT
SCHEMBL19086259	0.87	METTL3 (0.42)	METTL3PRMT5WDR77MAOBNAMPT
SCHEMBL19085979	0.87	MAOB (0.41)	METTL3PRMT5WDR77MAOBNAMPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2017114275-A1	COMPOUND FOR INHIBITING ROCK, PREPARATION METHOD AND USE OF SAME	成都先导药物开发有限公司	2017-07-06	—	—	WO	disclosed