SCHEMBL19085980 — predicted protein targets

Predicted protein targets (top 8)

	gene	UniProt	supporting neighbours	confidence
▸	PRMT5	O14744	13/20	0.40

▸	WDR77	Q9BQA1	13/20	0.40

▸	METTL3	Q86U44	1/20	0.38

▸	ROCK2	O75116	2/20	0.37

▸	ABL1	P00519	1/20	0.36

▸	NAMPT	P43490	2/20	0.36

▸	HDAC6	Q9UBN7	1/20	0.36

▸	ROCK1	Q13464	1/20	0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL19085997	0.90	PRMT5 (0.40)	PRMT5WDR77METTL3ROCK2ABL1
SCHEMBL19085992	0.90	PRMT5 (0.40)	PRMT5WDR77METTL3ROCK2ABL1
SCHEMBL19085986	0.88	PRMT5 (0.39)	PRMT5WDR77METTL3ROCK2ABL1
SCHEMBL19086223	0.86	METTL3 (0.43)	PRMT5WDR77METTL3ROCK2ABL1
SCHEMBL19086979	0.85	MAOB (0.39)	PRMT5WDR77METTL3ROCK2NAMPT
SCHEMBL19086000	0.85	KDM4E (0.39)	HDAC6
SCHEMBL19085979	0.83	MAOB (0.41)	PRMT5WDR77METTL3ROCK2NAMPT
SCHEMBL19086260	0.80	METTL3 (0.38)	PRMT5WDR77METTL3ROCK2NAMPT
SCHEMBL19086045	0.80	HDAC6 (0.43)	PRMT5WDR77ROCK2HDAC6ROCK1
SCHEMBL19086003	0.80	METTL3 (0.38)	PRMT5WDR77METTL3ROCK2NAMPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2017114275-A1	COMPOUND FOR INHIBITING ROCK, PREPARATION METHOD AND USE OF SAME	成都先导药物开发有限公司	2017-07-06	—	—	WO	disclosed