Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METTL3 | Q86U44 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 5/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 6/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 6/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.41 |
| ▸ | NAMPT | P43490 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.36 |
| ▸ | WNT3A | P56704 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19086259 | 0.89 | METTL3 (0.42) | METTL3KDM1AHDAC6PRMT5WDR77 | |
| SCHEMBL19085992 | 0.87 | PRMT5 (0.40) | METTL3PRMT5WDR77ROCK2NAMPT | |
| SCHEMBL19085997 | 0.87 | PRMT5 (0.40) | METTL3PRMT5WDR77ROCK2NAMPT | |
| SCHEMBL19085980 | 0.86 | PRMT5 (0.40) | METTL3HDAC6PRMT5WDR77ROCK2 | |
| SCHEMBL19086024 | 0.85 | MAOB (0.43) | METTL3KDM1AHDAC6PRMT5WDR77 | |
| SCHEMBL19085986 | 0.85 | PRMT5 (0.39) | METTL3PRMT5WDR77ROCK2NAMPT | |
| SCHEMBL19086208 | 0.85 | KDM1A (0.44) | KDM1AHDAC6PRMT5WDR77MAOB | |
| SCHEMBL19086026 | 0.85 | METTL3 (0.44) | METTL3KDM1AHDAC6PRMT5WDR77 | |
| SCHEMBL19086351 | 0.83 | MAOB (0.44) | METTL3KDM1AHDAC6PRMT5WDR77 | |
| SCHEMBL19086214 | 0.82 | METTL3 (0.48) | METTL3ROCK2MAOBALDH1A1CTNNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017114275-A1 | COMPOUND FOR INHIBITING ROCK, PREPARATION METHOD AND USE OF SAME | 成都先导药物开发有限公司 | 2017-07-06 | — | — | WO | disclosed |