Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 10/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 10/20 | 0.38 |
| ▸ | NAMPT | P43490 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19085984 | 0.94 | ROCK2 (0.42) | MAOBMETTL3PRMT5WDR77KDM4E | |
| SCHEMBL19086985 | 0.93 | PRMT5 (0.41) | MAOBMETTL3PRMT5WDR77NAMPT | |
| SCHEMBL19085995 | 0.90 | METTL3 (0.41) | MAOBMETTL3PRMT5WDR77NAMPT | |
| SCHEMBL19085994 | 0.89 | ROCK2 (0.41) | MAOBMETTL3PRMT5WDR77NAMPT | |
| SCHEMBL19086023 | 0.89 | NAMPT (0.38) | MAOBMETTL3PRMT5WDR77NAMPT | |
| SCHEMBL19086349 | 0.89 | MAOB (0.40) | MAOBMETTL3PRMT5WDR77NAMPT | |
| SCHEMBL19086994 | 0.88 | MAOB (0.39) | MAOBMETTL3PRMT5WDR77NAMPT | |
| SCHEMBL19086205 | 0.88 | MAOB (0.39) | MAOBMETTL3PRMT5WDR77NAMPT | |
| SCHEMBL19085996 | 0.88 | ROCK2 (0.53) | PRMT5WDR77NAMPTROCK2ROCK1 | |
| SCHEMBL19086039 | 0.88 | PRMT5 (0.39) | METTL3PRMT5WDR77ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017114275-A1 | COMPOUND FOR INHIBITING ROCK, PREPARATION METHOD AND USE OF SAME | 成都先导药物开发有限公司 | 2017-07-06 | — | — | WO | disclosed |