SCHEMBL19086994 — predicted protein targets

Predicted protein targets (top 11)

	gene	UniProt	supporting neighbours	confidence
▸	MAOB	P27338	1/20	0.39

▸	NAMPT	P43490	3/20	0.38

▸	METTL3	Q86U44	1/20	0.37

▸	PRMT5	O14744	8/20	0.36

▸	WDR77	Q9BQA1	8/20	0.36

▸	ROCK2	O75116	5/20	0.35

▸	KLKB1	P03952	1/20	0.35

▸	MAP4K1	Q92918	1/20	0.35

▸	KDM4E	B2RXH2	1/20	0.34

▸	ALDH1A1	P00352	1/20	0.34

▸	ROCK1	Q13464	2/20	0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL19086205	1.00	MAOB (0.39)	MAOBNAMPTMETTL3PRMT5WDR77
SCHEMBL19086349	0.93	MAOB (0.40)	MAOBNAMPTMETTL3PRMT5WDR77
SCHEMBL19086985	0.91	PRMT5 (0.41)	MAOBNAMPTMETTL3PRMT5WDR77
SCHEMBL19086234	0.91	EPHX2 (0.43)	MAOBNAMPTMETTL3PRMT5WDR77
SCHEMBL19086979	0.90	MAOB (0.39)	MAOBNAMPTMETTL3PRMT5WDR77
SCHEMBL19085994	0.90	ROCK2 (0.41)	MAOBNAMPTMETTL3PRMT5WDR77
SCHEMBL19086178	0.89	NPC1 (0.38)	MAOBROCK2ROCK1
SCHEMBL19085984	0.89	ROCK2 (0.42)	MAOBMETTL3PRMT5WDR77ROCK2
SCHEMBL19086260	0.89	METTL3 (0.38)	MAOBNAMPTMETTL3PRMT5WDR77
SCHEMBL19086023	0.89	NAMPT (0.38)	MAOBNAMPTMETTL3PRMT5WDR77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2017114275-A1	COMPOUND FOR INHIBITING ROCK, PREPARATION METHOD AND USE OF SAME	成都先导药物开发有限公司	2017-07-06	—	—	WO	disclosed