Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 14/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 13/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | MARK3 | P27448 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19085995 | 0.91 | METTL3 (0.41) | ROCK2ROCK1PRMT5WDR77MAPT | |
| SCHEMBL19085984 | 0.91 | ROCK2 (0.42) | ROCK2ROCK1PRMT5WDR77AURKA | |
| SCHEMBL19085994 | 0.91 | ROCK2 (0.41) | ROCK2ROCK1PRMT5WDR77MAPK1 | |
| SCHEMBL19085976 | 0.89 | DDR2 (0.46) | ROCK2ROCK1PRMT5WDR77NAMPT | |
| SCHEMBL19086234 | 0.89 | EPHX2 (0.43) | ROCK2ROCK1PRMT5WDR77NAMPT | |
| SCHEMBL19086041 | 0.88 | ROCK2 (0.40) | ROCK2ROCK1PRMT5WDR77MAPT | |
| SCHEMBL19085991 | 0.88 | MAOB (0.42) | ROCK2ROCK1PRMT5WDR77NAMPT | |
| SCHEMBL19086985 | 0.88 | PRMT5 (0.41) | ROCK2ROCK1PRMT5WDR77NAMPT | |
| SCHEMBL19086044 | 0.87 | PRMT5 (0.40) | ROCK2PRMT5WDR77CSNK1D | |
| SCHEMBL19086349 | 0.87 | MAOB (0.40) | ROCK2ROCK1PRMT5WDR77NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017114275-A1 | COMPOUND FOR INHIBITING ROCK, PREPARATION METHOD AND USE OF SAME | 成都先导药物开发有限公司 | 2017-07-06 | — | — | WO | disclosed |