SCHEMBL19086004 — predicted protein targets

Predicted protein targets (top 14)

	gene	UniProt	supporting neighbours	confidence
▸	PRMT5	O14744	4/20	0.39

▸	WDR77	Q9BQA1	4/20	0.39

▸	ROCK2	O75116	6/20	0.38

▸	ROCK1	Q13464	5/20	0.38

▸	KDM1A	O60341	4/20	0.37

▸	EGFR	P00533	1/20	0.37

▸	BRAF	P15056	1/20	0.37

▸	NPC1	O15118	1/20	0.36

▸	RAB9A	P51151	1/20	0.36

▸	HDAC6	Q9UBN7	3/20	0.35

▸	CTNNB1	P35222	1/20	0.35

▸	WNT3A	P56704	1/20	0.35

▸	ABL1	P00519	1/20	0.35

▸	METTL3	Q86U44	1/20	0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL19085982	0.91	KDM4E (0.39)	PRMT5WDR77ROCK2ROCK1KDM1A
SCHEMBL19085977	0.91	NPC1 (0.45)	PRMT5WDR77ROCK2ROCK1KDM1A
SCHEMBL19085992	0.90	PRMT5 (0.40)	PRMT5WDR77ROCK2ROCK1ABL1
SCHEMBL19085997	0.90	PRMT5 (0.40)	PRMT5WDR77ROCK2ROCK1ABL1
SCHEMBL19085987	0.90	KDM1A (0.41)	PRMT5WDR77ROCK2ROCK1KDM1A
SCHEMBL19085978	0.89	ROCK2 (0.46)	PRMT5WDR77ROCK2ROCK1NPC1
SCHEMBL19085993	0.89	BTK (0.38)	PRMT5WDR77ROCK2ROCK1NPC1
SCHEMBL19086258	0.89	ROCK2 (0.34)	PRMT5WDR77ROCK2ROCK1KDM1A
SCHEMBL19086144	0.89	ROCK2 (0.35)	PRMT5WDR77ROCK2ROCK1KDM1A
SCHEMBL19085999	0.86	TRPV1 (0.41)	PRMT5WDR77ROCK2ROCK1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2017114275-A1	COMPOUND FOR INHIBITING ROCK, PREPARATION METHOD AND USE OF SAME	成都先导药物开发有限公司	2017-07-06	—	—	WO	disclosed