SCHEMBL19086144 — predicted protein targets

Predicted protein targets (top 14)

	gene	UniProt	supporting neighbours	confidence
▸	ROCK2	O75116	10/20	0.35

▸	ROCK1	Q13464	7/20	0.35

▸	KDM1A	O60341	1/20	0.35

▸	HCRTR1	O43613	1/20	0.34

▸	HCRTR2	O43614	1/20	0.34

▸	ANPEP	P15144	1/20	0.34

▸	PRMT5	O14744	2/20	0.33

▸	WDR77	Q9BQA1	2/20	0.33

▸	HDAC6	Q9UBN7	2/20	0.33

▸	METTL3	Q86U44	1/20	0.33

▸	TRPV1	Q8NER1	1/20	0.32

▸	KDM4E	B2RXH2	1/20	0.32

▸	MAPT	P10636	1/20	0.32

▸	MAPK1	P28482	1/20	0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL19086145	0.90	ROCK2 (0.36)	ROCK2ROCK1PRMT5WDR77TRPV1
SCHEMBL19085987	0.89	KDM1A (0.41)	ROCK2ROCK1KDM1AHCRTR1HCRTR2
SCHEMBL19086004	0.89	PRMT5 (0.39)	ROCK2ROCK1KDM1APRMT5WDR77
SCHEMBL19085977	0.86	NPC1 (0.45)	ROCK2ROCK1KDM1APRMT5WDR77
SCHEMBL19086252	0.86	ROCK2 (0.37)	ROCK2ROCK1HCRTR1HCRTR2ANPEP
SCHEMBL19085993	0.86	BTK (0.38)	ROCK2ROCK1PRMT5WDR77METTL3
SCHEMBL19086258	0.85	ROCK2 (0.34)	ROCK2ROCK1KDM1APRMT5WDR77
SCHEMBL19085982	0.85	KDM4E (0.39)	ROCK2ROCK1KDM1AHCRTR1HCRTR2
SCHEMBL19085999	0.85	TRPV1 (0.41)	ROCK2ROCK1HCRTR2PRMT5WDR77
SCHEMBL19085981	0.85	TRPV1 (0.41)	ROCK2ROCK1HCRTR2PRMT5WDR77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2017114275-A1	COMPOUND FOR INHIBITING ROCK, PREPARATION METHOD AND USE OF SAME	成都先导药物开发有限公司	2017-07-06	—	—	WO	disclosed