SCHEMBL19085982

SCHEMBL19085982

CC[C@@H](NC(=O)c1ccc2[nH]ncc2c1)C(=O)N1CCc2sc(C(=O)Nc3cc(F)ccc3OC)cc2C1

nearest known ligand 0.39

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
RAB9A P51151 1/20 0.39
HCRTR2 O43614 4/20 0.39
HCRTR1 O43613 2/20 0.39
MAOB P27338 3/20 0.38
MAOA P21397 2/20 0.38
ALDH1A1 P00352 2/20 0.38
HPGD P15428 2/20 0.38
MAPT P10636 1/20 0.38
HTT P42858 1/20 0.38
ROCK2 O75116 3/20 0.37
ROCK1 Q13464 3/20 0.37
GPR55 Q9Y2T6 3/20 0.36
LMNA P02545 1/20 0.36
KDM1A O60341 1/20 0.36
CNR1 P21554 2/20 0.36
PRMT5 O14744 1/20 0.36
WDR77 Q9BQA1 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19086004 0.91 PRMT5 (0.39) RAB9AROCK2ROCK1KDM1APRMT5
SCHEMBL19086168 0.89 MAOB (0.38) KDM4ESMN1; SMN2RAB9AHCRTR2HCRTR1
SCHEMBL19086000 0.89 KDM4E (0.39) KDM4ESMN1; SMN2RAB9AHCRTR2HCRTR1
SCHEMBL19085977 0.89 NPC1 (0.45) KDM4ERAB9AMAOBMAPTROCK2
SCHEMBL19085987 0.88 KDM1A (0.41) SMN1; SMN2RAB9AHCRTR2HCRTR1ALDH1A1
SCHEMBL19085978 0.87 ROCK2 (0.46) RAB9AMAOBMAOAROCK2ROCK1
SCHEMBL19086208 0.86 KDM1A (0.44) KDM4ESMN1; SMN2RAB9AMAOBMAOA
SCHEMBL19086256 0.86 NPC1 (0.41) RAB9AMAOBMAOAROCK2ROCK1
SCHEMBL19086258 0.85 ROCK2 (0.34) ROCK2ROCK1KDM1APRMT5WDR77
SCHEMBL19086144 0.85 ROCK2 (0.35) KDM4EHCRTR2HCRTR1MAPTROCK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017114275-A1 COMPOUND FOR INHIBITING ROCK, PREPARATION METHOD AND USE OF SAME 成都先导药物开发有限公司 2017-07-06 WO disclosed