SCHEMBL19086168

SCHEMBL19086168

CC[C@@H](NC(=O)c1ccc2[nH]ncc2c1)C(=O)N1CCc2sc(C(=O)Nc3cn(C)cc3OC)cc2C1

nearest known ligand 0.38

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MAOB P27338 5/20 0.38
MAOA P21397 3/20 0.38
HCRTR2 O43614 5/20 0.38
ROCK2 O75116 5/20 0.36
ROCK1 Q13464 3/20 0.36
HCRTR1 O43613 3/20 0.36
METTL3 Q86U44 1/20 0.36
PRMT5 O14744 1/20 0.35
WDR77 Q9BQA1 1/20 0.35
KDM4E B2RXH2 2/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
ALDH1A1 P00352 1/20 0.35
MAPT P10636 1/20 0.35
HPGD P15428 1/20 0.35
HTT P42858 1/20 0.35
RAB9A P51151 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19085982 0.89 KDM4E (0.39) MAOBMAOAHCRTR2ROCK2ROCK1
SCHEMBL19086167 0.86 METTL3 (0.37) MAOBMAOAROCK2METTL3RAB9A
SCHEMBL19086160 0.85 HDAC6 (0.38) ROCK2ROCK1METTL3PRMT5WDR77
SCHEMBL19085987 0.85 KDM1A (0.41) HCRTR2ROCK2ROCK1HCRTR1PRMT5
SCHEMBL19085981 0.85 TRPV1 (0.41) MAOBMAOAHCRTR2ROCK2ROCK1
SCHEMBL19085999 0.85 TRPV1 (0.41) MAOBMAOAHCRTR2ROCK2ROCK1
SCHEMBL19086256 0.85 NPC1 (0.41) MAOBMAOAROCK2ROCK1PRMT5
SCHEMBL19085993 0.84 BTK (0.38) ROCK2ROCK1METTL3PRMT5WDR77
SCHEMBL19086169 0.84 METTL3 (0.37) MAOBMAOAROCK2ROCK1METTL3
SCHEMBL19086004 0.84 PRMT5 (0.39) ROCK2ROCK1METTL3PRMT5WDR77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017114275-A1 COMPOUND FOR INHIBITING ROCK, PREPARATION METHOD AND USE OF SAME 成都先导药物开发有限公司 2017-07-06 WO disclosed