Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | ANPEP | P15144 | 2/20 | 0.33 |
| ▸ | RNPEP | Q9H4A4 | 2/20 | 0.33 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | CTSD | P07339 | 1/20 | 0.32 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | NEU4 | Q8WWR8 | 1/20 | 0.30 |
| ▸ | NEU1 | Q99519 | 1/20 | 0.30 |
| ▸ | NEU2 | Q9Y3R4 | 1/20 | 0.30 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22175199 | 0.82 | KDM4C (0.40) | CA1P2RX7ALDH1A1PIK3CDKCNJ11 | |
| SCHEMBL19116861 | 0.80 | PTPN1 (0.36) | ALDH1A1PIK3CD | |
| SCHEMBL17771181 | 0.79 | CA1 (0.44) | CA1P2RX7ALDH1A1PIK3CD | |
| SCHEMBL9253803 | 0.78 | CTSD (0.48) | CA1ALDH1A1CTSD | |
| SCHEMBL19750428 | 0.77 | CA1 (0.39) | CA1P2RX7ALDH1A1PIK3CD | |
| SCHEMBL19389216 | 0.74 | ALDH1A1 (0.46) | CA1P2RX7ALDH1A1 | |
| SCHEMBL9112217 | 0.73 | CA1 (0.39) | CA1P2RX7ALDH1A1PIK3CDKCNJ11 | |
| SCHEMBL9112225 | 0.73 | CA1 (0.39) | CA1P2RX7ALDH1A1PIK3CDKCNJ11 | |
| SCHEMBL20767063 | 0.73 | CA1 (0.35) | CA1P2RX7ALDH1A1ANPEPRNPEP | |
| SCHEMBL18518150 | 0.73 | MEN1 (0.36) | ALDH1A1CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210214315-A1 | 3-((Hetero-)Aryl)-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives | Grünenthal GmbH (DE) | 2021-07-15 | — | — | US | disclosed |
| US-20200399226-A1 | 3-((Hetero-)Aryl)-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives | Grünenthal GmbH (DE) | 2020-12-24 | — | — | US | disclosed |
| US-20200331864-A1 | 1,3-DIAZA-SPIRO-[3.4]-OCTANE DERIVATIVES | GRUNENTHAL GMBH (DE) | 2020-10-22 | — | — | US | disclosed |
| US-10793528-B2 | 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives | Grünenthal GmbH (DE) | 2020-10-06 | — | — | US | disclosed |
| US-10738015-B2 | 1,3-diaza-spiro-[3.4]-octane derivatives | Grünenthal GmbH (DE) | 2020-08-11 | — | — | US | disclosed |
| US-20190100497-A1 | 3-(CARBOXYETHYL)-8-AMINO-2-OXO-1,3-DIAZA-SPIRO-[4.5]-DECANE DERIVATIVES | Grünenthal GmbH (DE) | 2019-04-04 | — | — | US | disclosed |
| US-20190016685-A1 | 1,3-DIAZA-SPIRO-[3.4]-OCTANE DERIVATIVES | Grünenthal GmbH (DE) | 2019-01-17 | — | — | US | disclosed |
| WO-2017121646-A1 | 3-(CARBOXYETHYL)-8-AMINO-2-OXO-1,3-DIAZA-SPIRO-[4.5]-DECANE DERIVATIVES | Grünenthal GmbH (DE) | 2017-07-20 | — | — | WO | disclosed |
| US-20170197919-A1 | 3-(Carboxyethyl)-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives | GRUENENTHAL GMBH (DE) | 2017-07-13 | — | — | US | disclosed |
| US-20170197919-A1 | 3-(Carboxyethyl)-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives | GRUENENTHAL GMBH (DE) | 2017-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190016685-A1 | 1,3-DIAZA-SPIRO-[3.4]-OCTANE DERIVATIVES | OPRK1, OPRD1, OPRL1 | CA1 4329/4885P2RX7 392/4885ALDH1A1 32/4885 |
| US-10738015-B2 | 1,3-diaza-spiro-[3.4]-octane derivatives | OPRK1, OPRD1, OPRL1 | CA1 4329/4885P2RX7 392/4885ALDH1A1 32/4885 |
| US-20210214315-A1 | 3-((Hetero-)Aryl)-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives | OPRK1, OPRD1, OPRL1 | CA1 3964/4885P2RX7 104/4885ALDH1A1 437/4885 |
| US-20200331864-A1 | 1,3-DIAZA-SPIRO-[3.4]-OCTANE DERIVATIVES | OPRK1, OPRD1, OPRL1 | CA1 4329/4885P2RX7 392/4885ALDH1A1 32/4885 |
| US-20170197919-A1 | 3-(Carboxyethyl)-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives | OPRK1, OPRD1, PKD1 | CA1 2349/4885P2RX7 82/4885ALDH1A1 472/4885 |
| US-20200399226-A1 | 3-((Hetero-)Aryl)-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives | OPRK1, OPRD1, OPRL1 | CA1 3964/4885P2RX7 104/4885ALDH1A1 437/4885 |
| US-20190100497-A1 | 3-(CARBOXYETHYL)-8-AMINO-2-OXO-1,3-DIAZA-SPIRO-[4.5]-DECANE DERIVATIVES | OPRK1, OPRD1, PKD2 | CA1 3086/4885P2RX7 149/4885ALDH1A1 317/4885 |
| US-10793528-B2 | 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives | OPRK1, OPRD1, OPRL1 | CA1 3964/4885P2RX7 104/4885ALDH1A1 437/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.