Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 8/20 | 0.34 |
| ▸ | CTSL | P07711 | 6/20 | 0.33 |
| ▸ | CTSB | P07858 | 6/20 | 0.33 |
| ▸ | CTSH | P09668 | 4/20 | 0.32 |
| ▸ | SHBG | P04278 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13889045 | 1.00 | CYP1A2 (0.34) | CYP1A2CTSKCTSLCTSBCTSH | |
| SCHEMBL12849238 | 0.79 | CTSK (0.36) | CYP1A2CTSKCTSLCTSBCTSH | |
| SCHEMBL1911353 | 0.79 | CTSK (0.36) | CYP1A2CTSKCTSLCTSBCTSH | |
| SCHEMBL90304 | 0.78 | DPP4 (0.35) | CYP1A2 | |
| SCHEMBL89518 | 0.78 | DPP4 (0.35) | CYP1A2 | |
| SCHEMBL3155857 | 0.78 | CYP1A2 (0.40) | CYP1A2CTSKCTSLCTSBCTSH | |
| SCHEMBL8605603 | 0.78 | CTSK (0.38) | CTSKCTSLCTSBCTSH | |
| SCHEMBL28098164 | 0.77 | CYP1A2 (0.43) | CYP1A2CTSKCTSLCTSBCTSH | |
| SCHEMBL2422889 | 0.76 | SHBG (0.42) | CYP1A2CTSKCTSLCTSBSHBG | |
| SCHEMBL24428763 | 0.74 | NCF1 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2420491-B1 | 3 , 5-SUBSTITUED PIPERIDINE COMPOUNDS AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2013-07-03 | — | — | EP | disclosed |
| EP-2420491-A1 | 3 , 5-substitued piperidine compounds as renin inhibitors | Novartis AG (CH) | 2012-02-22 | — | — | EP | disclosed |
| WO-2007077005-A1 | 3 , 5-SUBSTITΓUED PIPERIDINE COMPOUNDS AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2007-07-12 | — | — | WO | disclosed |