Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KLK7 | P49862 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19119401 | 0.80 | ALDH1A1 (0.53) | MAPK1KLK7HSD17B10SMN1; SMN2KMT2A | |
| SCHEMBL4014858 | 0.80 | LMNA (0.47) | LMNAMAPK1KLK7HPGDCES2 | |
| SCHEMBL4485794 | 0.79 | LMNA (0.54) | LMNAMAPK1KLK7HPGDCES2 | |
| SCHEMBL4485798 | 0.79 | LMNA (0.54) | LMNAMAPK1KLK7HPGDCES2 | |
| SCHEMBL19107052 | 0.79 | LMNA (0.46) | LMNAMAPK1KLK7HPGDCES2 | |
| SCHEMBL19120157 | 0.77 | LMNA (0.60) | LMNAMAPK1HPGDCES2CES1 | |
| SCHEMBL19119845 | 0.77 | LMNA (0.60) | LMNAMAPK1HPGDCES2CES1 | |
| SCHEMBL19119528 | 0.74 | ALDH1A1 (0.41) | LMNAMAPK1KLK7HPGDKMT2A | |
| SCHEMBL821949 | 0.73 | LMNA (0.47) | LMNAMAPK1HPGDCES2CES1 | |
| SCHEMBL17766275 | 0.73 | MAPT (0.54) | LMNAMAPK1KLK7HPGDCES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170196851-A1 | Novel Alpha-Hydroxy Carboxylic Acid And Derivatives And Other Gras- Based Prodrugs Of Opioids And Uses Thereof | THOTTATHIL JOHN K (US) | 2017-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170196851-A1 | Novel Alpha-Hydroxy Carboxylic Acid And Derivatives And Other Gras- Based Prodrugs Of Opioids And Uses Thereof | OPRD1, OPRK1, OPRM1 | LMNA 3944/4885MAPK1 3038/4885KLK7 3053/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.